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Targets of TME pathways

BACKGROUND

According to the data from The Global Cancer Observatory (GCO), cancer is now one of the most serious diseases worldwide with around 20 million new cases and nearly 9.6 million deaths. In addition to a wide range of genetic and epigenetic alterations, components of the tumor microenvironment have a major impact on tumor progression. The tumor microenvironment (TME) is the environment around tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). These cellular and non-cellular components of TME can reprogram the processes of tumor occurrence and development by regulating different cascade signaling pathways. Therefore, understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to disrupt cancer development and contribute to the development of efficient and safe therapeutic strategies to fight cancer.

Nowadays, the TME becomes a hot area for antibody drug development and cancer treatment. ACROBiosystems have developed a series of TME related targets, such as TGF-β, Notch, etc., helping for cancer treatment and fast your R&D procedure.

HOT TARGETS
TGF-β
  1. > Cytokines with pleiotropic biological activities

  2. > Promote angiogenesis and migration in TME

  3. > Inhibit immune system by regulating the function of immune cell groups in the TME


Notch
  1. > Regulate the cell differentiation, apoptosis, proliferation and cell boundary formation

  2. > High expression in malignant tumors

  3. > Interact with FGF and Wnt signaling pathways, maintain cancer stem cell (CSC) growth and reshape the TME

Integrin
  1. > Cell adhesion molecules

  2. > Cell adhesion receptor with the function of signal transduction

  3. > Have a crucial role in tumor angiogenesis, progression, and metastasis


VEGF
  1. > A potent angiogenic factor

  2. > Play a crucial role in promoting angiogenesis and regeneration

  3. > Have some other multiple functions such as immune regulation and neuroprotection


PRODUCT LIST

Click on the molecule to find some details

ASSAY DATA
High purity——MALS verified
DLL3(DL3-H52H4
The purity of Human DLL3, His Tag(Cat. No. DL3-H52H4) is more than 95% and the molecular weight of this protein is around 55-65 kDa verified by SEC-MALS.
High bioactivity
> ELISA
TGF-beta 1(TG1-H4212
Immobilized ActiveMax® Human TGFB1, Tag Free (Cat. No. TG1-H4212) at 0.2 μg/mL (100 μL/well) can bind Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) with a linear range of 0.08-1 ng/mL (QC tested).

> BLI
NOTCH2(NO2-H5255
Loaded Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 77.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
> SPR
HGF R(MET-H5256
Human HGF R Protein, Fc Tag (Cat. No. MET-H5256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HGF Protein, His Tag (Cat. No. HGF-H52H3) with an affinity constant of 75.2 pM as determined in a SPR assay (Biacore 8K) (QC tested).

Related Article

> How TGF-β controls the tumor microenvironment

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