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Your Position: Home > VEGF-B

VEGF-B

Brief Information

Name:Vascular endothelial growth factor B
Target Synonym:VEGF-related factor,VRF,VEGFB,VEGF-B,VEGFL,Vascular Endothelial Growth Factor B
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

Synonym Name

VRF,VEGFL,VEGFB,VEGF-B

Background

Vascular endothelial growth factor B (VEGFB) is also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AAV.7m8-aflibercept (Adverum Biotechnologies) ADVM-022 Phase 1 Clinical Adverum Biotechnologies Macular Degeneration Details
CSL-346 2H-10; CSL-346 Phase 2 Clinical Csl Ltd Diabetes Mellitus, Type 2; Diabetic Nephropathies Details

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