>Anti-Idiotypic Antibody Development Service
Anti-idiotypic antibody is an antibody that recognizes the variable region of another antibody thus producing a specific binding. Anti-idiotypic antibodies are widely used in drug development. They can be used as an important reference for immunogenicity analysis and can specifically detect antibody drug levels in the body. Anti-idiotypic antibody is, therefore, an important reagent for pharmacokinetics research.
As a global brand focusing on protein technology, products, and services in the development of biological drugs, ACROBiosystems is committed to providing high quality target antigens and key reagents and related services required in the development of targeted therapeutic drugs. ACRO provides series of anti-idiotypic antibodies with high affinity, high specificity, and high sensitivity. At the same time, in order to meet the diverse needs of customers, ACRO also provides one-stop services from antigen preparation to monoclonal anti-idiotype antibody, polyclonal anti-idiotype antibody, pharmacokinetic and immunogenicity test kit developments.
Anti-idiotypic rabbit polyclonal antibody preparation
One-on-one service of the project team, according to your needs, we will issue a customized plan for you
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Anti-idiotypic mouse monoclonal antibody preparation
Development of a quantitative detection kit for blood drug concentration
Monoclonal anti-idiotypic antibodies can be used in the detection of free type, bound type and total antibody drugs in pharmacokinetic studies. According to the antibody drug subtype, ACROBiosystems can provide anti-idiotypic antibodies of antigen-neutralizing and non-neutralizing subtypes.
Highly sensitive and diverse polyclonal anti-idiotypic antibodies can be used as a positive reference in immunogenicity studies, simulating the production of ADA inside the human body. ACROBiosystems can provide high-affinity and specific polyclonal anti-idiotypic antibody development services with short service cycles and low development costs.
Pharmacokinetic (PK) is a subject that quantitatively studies the absorption, distribution, metabolism, and excretion of drugs in organisms. Since blood is the medium for the absorption, distribution, metabolism and excretion of any drugs and their metabolites in the body, the drug concentration in various body fluids and tissues have proportional relationship with the drug concentration in the blood. In order to facilitate the preclinical and clinical PK research of antibody drugs, it is particularly important to design an accurate experimental method to determine the blood drug concentration.
ACROBiosystems can customize and develop blood drug concentration detection kits for customers' diversified needs and applications while also providing key reagents for PK and immunogenicity analysis of biological drugs such as monoclonal antibodies, bispecific antibody, ADC, CAR-T, etc.
|Antigen capture ELISA||CD20||Antibodies to be tested||Goat anti-human IgG|
|Anti-idiotypic capture ELISA||Anti-Rituximab Antibodies||Antibodies to be tested||Goat anti-human IgG|
|Bridging ELISA by anti-idiotypic antibodies||Anti-Rituximab Antibodies||Antibodies to be tested||Biotinylated Anti-Rituximab Antibodies|
|Testing method||Linear range|
|Antigen-capture ELISA||—||—||Simple method and good versatility||High background, no activity|
|Anti-idiotypic capture ELISA||0.156-10||0.156||Solve the difficulty in obtaining CD20, simple method||High background, only suitable for Rituxa biosimilar|
|Bridging ELISA by anti-idiotypic antibodies||0.012-0.78||0.012||Solve the difficulty in obtaining CD20, good sensitivity and low background||Only applicable to Rituxan biosimilar|
Fast response, one-on-one service of the project team, real-time follow-up of the experiment progress
Provide key reagents for PK/ADA analysis for a variety of drugs (monoclonal antibody, bispecific antibody, ADC, CAR-T)
Provide one-stop service from antigen preparation to monoclonal anti-idiotype antibodies, polyclonal anti-idiotype antibodies, PK and immunogenicity test kit developments
Ensure delivery of PK/ADA test kits with sensitivity that meets regulatory requirements
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