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Your Position: Home > Hemagglutinin (HA)

Hemagglutinin (HA)

Brief Information

Name:Influenza virus hemagglutinin glycoproteins
Target Synonym:Hemagglutinin,HA,Hemagglutinin Glycoproteins, Influenza Virus
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

HA1-V5229-ELISA
Influenza A [A/Hong Kong/483/97 (H5N1)] HA, His TagInfluenza A [A/Hong Kong/483/97 (H5N1)] HA, His Tag (Cat. No. HA1-V5229) ELISA bioactivity

Immobilized Influenza A [A/Hong Kong/483/97 (H5N1)] HA, His Tag (Cat. No. HA1-V5229) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Influenza HA Universal Antibody, Human IgG1 with a linear range of 2-78 ng/mL (QC tested).

HA1-V5229-MALS-HPLC
Influenza A [A/Hong Kong/483/97 (H5N1)] HA, His Tag (Cat. No. ) MALS images

The purity of Influenza A [A/Hong Kong/483/97 (H5N1)] HA, His Tag (Cat. No. HA1-V5229) is more than 90% and the molecular weight of this protein is around 70-80 kDa verified by SEC-MALS.

Bioactivity-ELISA
Influenza A [A/Hong Kong/483/97 (H5N1)] HA, His TagInfluenza A [A/Hong Kong/483/97 (H5N1)] HA, His Tag (Cat. No. HA1-V5229) ELISA bioactivity

Immobilized Influenza A [A/Hong Kong/483/97 (H5N1)] HA, His Tag (Cat. No. HA1-V5229) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Influenza HA Universal Antibody, Human IgG1 with a linear range of 2-78 ng/mL (QC tested).

Synonym Name

HA,Hemagglutinin

Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Hemagglutinin also plays a major role in the determination of host range restriction and virulence. As a class I viral fusion protein, hemagglutinin is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-influenza monoclonal antibody (AIMM Therapeutics) Phase 1 Clinical Aimm Therapeutics Influenza, Human Details
MEDI-8852 MEDI-8852 Phase 2 Clinical Humabs Biomed Influenza, Human Details
Gedivumab RG-7745; MHAA-4549A Phase 2 Clinical Genentech Inc Influenza A virus infections; Influenza, Human Details
Diridavumab CR-6261; JNJ-54235025 Phase 2 Clinical Crucell Holland Bv Influenza, Human Details
Navivumab/Firivumab CT-P27 Phase 2 Clinical Celltrion Influenza A virus infections Details
mRNA-1851 mRNA-1851; VAL-339851 Phase 1 Clinical Valera Llc Influenza A virus infections; Influenza, Human Details
VIS-410 VIS-410 Phase 2 Clinical Influenza A virus infections; Influenza, Human Details

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