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Spare 1 minute for the survey of bispecific antibody, get the gift of your choice from us!
Thank you for choosing ACROBiosystems. Would you rate our product and service？
Spare 1 minute for the survey of bispecific antibody, get the gift of your choice from us!
A-Z> Solutions for COVID-19 vaccine safety and immunogenicity evaluation
With the efforts of the scientist around the world, up until now, there are now several COVID-19 vaccines that are in use.
In the development of a COVID-19 vaccine, safety and immunogenicity evaluation are indispensable and well-established assays are required for fast and convenient assessment of the vaccine candidates.
Based on advanced technology platform in recombinant protein production, ACROBiosystems has developed a series of critical reagents for COVID-19 vaccine development and evaluation, including ELISA kits, recombinant proteins and antibodies. These featured products are suitable for IgG/M antibody titer detection, neutralizing antibody titer detection and antigen titer detection to accelerate the vaccine development.
Detection of Monoclonal Anti-SARS-CoV-2 Antibody, Human IgG1 titer by Indirect-ELISA Assay. Immobilized SARS-CoV-2 Spike RBD at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-SARS-CoV-2 Antibody, Human IgG1 in 1:400 human serum. Detection was performed using HRP-Anti-human IgG antibody with sensitivity of 98 ng/mL
Fig 1. The purity of SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) was more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.
Fig 2. Immobilized Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) at 1 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) with a linear range of 0.3-10 ng/mL
Fig 3. Immobilized Biotinylated SARS-CoV-2 S protein RBD, His,Avitag (Cat. No. SPD-C82E9) at 1 μg/mL (100 μL/well) on Streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Monoclonal Anti-SARS-CoV-S protein RBD Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL
Pfizer employed ACROBiosystems' featured biotinylated S protein RBD in the RBD-binding IgG assay during the phase 1/2 research. The interim report showed that the biotinylated S protein RBD from ACROBiosystems （Cat.No. SPD-C82E9）was bound to streptavidin-coated Luminex microspheres.[1]
Correlation analysis of RAS-N022 and FDA approved ELISA kit (detection of neutralizing antibody in post-vaccination serum)
Fig 5. Immobilized SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3) at 1 μg/mL (100 μL/well) can bind Anti-SARS-CoV-2 RBD Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) with a linear range of 0.1-3 ng/mL
Fig 8. This assay kit employs a standard sandwich-ELISA format, providing a rapid detection of SARS-CoV-2 Spike protein. The kit consists of pre-coated Anti-SARS-CoV-2 Spike Protein Antibody Microplate, SARS-CoV-2 Spike protein as Control, biotin-Anti-SARS-CoV-2 Spike protein antibody and HRP-Streptavidin. Detection is performed using HRP-Streptavidin with sensitivity of 200 pg/mL.
Fig.4 cross-validation data for antibody subtype detection
>>> related article：SARS-CoV-2 Infection: Do You Know About the Antibody-Dependent Enhancement (ADE)?
| Molecule | Cat. No. | Product Description |
|---|---|---|
| ACE2 protein | AC2-H52H8 | Human ACE2 / ACEH Protein, His Tag (MALS verified) |
| AC2-H82E6 | Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified) | |
| AC2-H5257 | Human ACE2 / ACEH Protein, Fc Tag (MALS verified) | |
| AC2-H82F9 | Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™ | |
| S trimer protein | SPN-C52H9 | SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS & NS-EM verified) |
| SPN-C82E9 | Biotinylated SARS-CoV-2 S protein, His,Avitag™, Super stable trimer (MALS verified) | |
| SPN-C52H3 | SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified) | |
| SPN-C82E3 | Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified) | |
| S protein RBD | SPD-C52H3 | SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified) |
| SPD-C82E9 | Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified) | |
| SPD-C5259 | SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag(MALS verified) | |
| SPD-C82Aa | Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG1 Fc,Avitag™(MALS verified) | |
| S1 protein | S1N-C52H4 | SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified) |
| S1N-C82E8 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified) | |
| S1N-C5256 | SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag | |
| S1N-C82E3 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™ | |
| S1 protein NTD | S1D-C52H6 | SARS-CoV-2 (COVID-19) S1 protein NTD, His Tag |
| S1 protein CTD | S1D-C52H3 | SARS-CoV-2 (COVID-19) S1 protein CTD, His Tag (MALS-verified) |
| S2 protein | S2N-C52H5 | SARS-CoV-2 (COVID-19) S2 protein, His Tag |
| Nucleocapsid protein | NUN-C5227 | SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag |
| NUN-C82E8 | Biotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™ |
Antibody titer assay kits
Antigen titer assay kits
Inhibitor screening kits and more
| Category | Species | Cat.No. | Product Description | sample | Preorder/Order |
|---|---|---|---|---|---|
| Neutralizing antibody titer assay kit | Wild Type | RAS-N022 | Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit | Human Serum | |
Alpha | B.1.1.7 (U.K.) | RAS-N028 | Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
Beta | B.1.351 (South Africa) | RAS-N031 | Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
Gamma | P.1 (Brazil) | RAS-N034 | Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
Delta | B.1.617.2 (India) | RAS-N040 | Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike RBD) | Human Serum | ||
| RAS-N041 | Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike Trimer) | Human Serum | |||
| Antibody titer assay kit | Wild Type | RAS-T024 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T025 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | Human Serum | |||
| RAS-T001 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1) | Human Serum | |||
| RAS-T008 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein) | Human Serum | |||
| RAS-T009 | Anti-SARS-CoV-2 Total Antibody Titer Serologic Assay kit (Spike RBD) | Human Serum | |||
| RAS-T012 | Anti-SARS-CoV-2 Antibody IgM Titer Serologic Assay Kit (Spike S1) | Human Serum | |||
| RAS-T013 | Anti-SARS-CoV-2 Antibody IgM Titer Serologic Assay Kit (Spike RBD) | Human Serum | |||
| RAS-T018 | Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit | Mouse Serum | |||
| RAS-T023 | Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | Mouse Serum | |||
| RAS-T019 | Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit | Monkey Serum | |||
Alpha | B.1.1.7 (U.K.) | RAS-T026 | Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
| RAS-T027 | Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | Human Serum | |||
Beta | B.1.351 (South Africa) | RAS-T029 | Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
| RAS-T030 | Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | Human Serum | |||
Gamma | P.1 (Brazil) | RAS-T032 | Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
| RAS-T033 | Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | Human Serum | |||
| Antibody isotype assay kit | Wild Type | RAS-T014 | Anti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay kit | Human Serum | |
| RAS-T015 | Anti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay kit | Human Serum | |||
| RAS-T016 | Anti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay kit | Human Serum | |||
| RAS-T017 | Anti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay kit | Human Serum |
| Cat.No. | Product Description | sample | Preorder/Order |
|---|---|---|---|
| RAS-A010 | SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit | Human Serum | |
| RAS-A020 | SARS-CoV-2 Spike Protein Titer Assay Kit | Human Serum | |
| RAS-A021 | SARS-CoV-2 Spike RBD Titer Assay Kit | Human Serum |
| Lineage | Cat.No. | Product Description | sample | Preorder/Order |
|---|---|---|---|---|
| SARS-CoV-2 (WT) | EP-105 | SARS-CoV-2 (COVID-19) Inhibitor screening Kit | anti-viral drug | |
| EP-107 | SARS-CoV-2 (WT) Inhibitor Screening Kit (Spike RBD) | anti-viral drug | ||
| SARS-CoV-2 Alpha | B.1.1.7 (U.K.) | EP-108 | SARS-CoV-2 (B.1.1.7) Inhibitor Screening Kit (Spike RBD) | anti-viral drug | |
| SARS-CoV-2 Beta | B.1.351 (South Africa) | EP-109 | SARS-CoV-2 (B.1.351) Inhibitor Screening Kit (Spike RBD) | anti-viral drug | |
| SARS-CoV-2 Gamma | P.1 (Brazil) | EP-110 | SARS-CoV-2 (P.1) Inhibitor Screening Kit (Spike RBD) | anti-viral drug | |
| SARS-CoV-2 Delta | B.1.617.2 (India) | EP-111 | SARS-CoV-2 (B.1.617.2) Inhibitor Screening Kit (Spike RBD) | anti-viral drug | |
| SP-12 | SARS-CoV-2 Spike S1 protein-Coated Plates, Clear, 96-Well | Human Serum | ||
| RP-13 | SARS-CoV-2 Spike protein RBD-Coated Plates, Clear, 96-Well | Human Serum |
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