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Your Position: Home > high-throughput solutions for vaccine R&D based on ELISA

high-throughput solutions for vaccine R&D based on ELISA

Background

Vaccination is one of the most important and economic tools to protect the community from infectious diseases. There are about 60% of the population were fully vaccinated around the world, however, as the virus mutates continuously, the increasingly strong transmission and immune escape capabilities of the mutant strains have brought great challenges to the prevention and control of the epidemic. The emergence of many breakthrough infection cases represents that the "immune barrier" created by vaccination against the wild-type strain of COVID-19 may be flawed. Therefore we urgently need next-generation vaccines that still have high protective efficacy against mutant strains.

As the world experiences a new wave of outbreaks due to the emergence of the Omicron variant, vaccine manufacturers have already stepped up for the development of vaccines against new variants. Earlier, Moderna and Pfizer had announced to start the research on candidate vaccines against Delta and Omicron variants. In China, the China Center for Disease Control and Prevention, Sinovac and Sinopharm Group received the Omicron variant virus isolated by HKU and began their work. In addition, CanSino Bio said they were also working on the development of a new vaccine against the Omicron variant.

In order to support and regulate the development of COVID-19 vaccines, the Food and Drug Administration (FDA) issued the "Development and Licensure of Vaccines to Prevent COVID-19" to determine key indicators for monitoring the whole process of vaccine development.

>>> click to download the Development and Licensure of Vaccines to Prevent COVID-19

ACROBiosystems has undergone methodological validation and independently developed a series of COVID-19-related ELISA kits according to the application as described in the guidelines, aiming to provide comprehensive solutions ranging from quality control of vaccine production to preclinical and clinical research.

Advantages:
- For wild type and VOCs (Alpha, Beta, Gamma, Delta, Omicron) detection;
- Can detect antigens and antibodies (including neutralizing antibodies, total antibodies, IgG, IgM, IgG antibody subtypes, etc.);
- Cover species of Human, Mouse and Monkey, to meet the needs of preclinical and clinical research;
- Strict quality control to ensure that the batch-to-batch difference and precision < 10%;
- High throughput, can detect 90+ samples within 2 hours;
- Low environmental requirements, simple operation.
Manufacture and quality control

Variant-specific antigen detection

Product list
LineageCat. No.Product DescriptionSamplePreorder/Order
SARS-CoV-2
Delta
B.1.617.2
RAS-A055SARS-CoV-2 Spike Trimer (B.1.617.2)  Specific ELISA Kit (For Vaccine Development)Vaccine samples

Order

SARS-CoV-2
Omicron
B.1.1.529
RAS-A081SARS-CoV-2 Spike Trimer (B.1.1.529) Specific ELISA Kit (For Vaccine Development)Vaccine samples

Order

RAS-A082SARS-CoV-2 Spike RBD (B.1.1.529) Specific ELISA Kit (For Vaccine Development)Vaccine samples

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Assay Data

SARS-CoV-2 Spike RBD (B.1.1.529) Specific ELISA Kit (For Vaccine Development)(Cat. No. RAS-A082) can specifically detect SARS-CoV-2 Spike RBD, His Tag (B.1.1.529/Omicron) (Cat. No. SPD-C522e), and cannot detect the spike RBD of other strains, inchuding WT,Alpha,Beta,Gamma and Delta.

Antigen detection

Product list
Cat. No.Product DescriptionSamplePreorder/Order
RAS-A010SARS-CoV-2 Nucleocapsid Protein Titer Assay KitVaccine samples

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RAS-A020SARS-CoV-2 Spike Protein Titer Assay KitVaccine samples

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RAS-A021SARS-CoV-2 Spike RBD Titer Assay KitVaccine samples

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RAS-A039SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development)Vaccine samples

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RAS-A050SARS-CoV-2 Spike RBD ELISA Kit (For Vaccine Development)Vaccine samples

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Assay Data

Immobilized Anti-SARS-CoV-2 Spike Protein Antibody at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 Spike Protein. Detection was performed using HRP-Anti-SARS-CoV-2 Spike Protein Antibody with sensitivity of 20 ng/mL (QC tested).

Preclinical research (Animal models)

Immunogenicity assay

Product list
LineageMoleculeCat. No.SampleProduct DescriptionPreorder/Order
SARS-CoV-2
Omicron
B.1.1.529
Spike RBDRAS-T059Mouse SerumMouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

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Spike proteinRAS-T060Mouse SerumMouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

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Spike S1RAS-T061Mouse SerumMouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)

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Spike RBDRAS-T062Monkey SerumMonkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Preorder

Spike proteinRAS-T063Monkey SerumMonkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

Preorder

Spike S1RAS-T064Monkey SerumMonkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)

Preorder

SARS-CoV-2
Omicron
B.A.2
Spike RBDRAS-T088Mouse SerumMouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Preorder

Spike proteinRAS-T089Mouse SerumMouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

Preorder

Spike S1RAS-T090Mouse SerumMouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike S1)

Preorder

SARS-CoV-2
Delta
Spike proteinRAS-T070Mouse SerumMouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

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Spike S1RAS-T086Mouse SerumMouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike S1)

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Spike RBDRAS-T091Mouse SerumMouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Preorder

SARS-CoV-2
Beta
B.1.351
Spike S1RAS-T084Mouse SerumMouse Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike S1)

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SARS-CoV-2
wild type
Spike RBDRAS-T018Mouse SerumMouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit

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Spike proteinRAS-T023Mouse SerumMouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

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Spike S1RAS-T045Mouse SerumMouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

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Spike RBDRAS-T019Monkey SerumMonkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit

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Spike proteinRAS-T046Monkey SerumMonkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

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Spike S1RAS-T047Monkey SerumMonkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

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Assay Data

Cat. No. RAS-T045 can be used to detect the mouse IgG antibody titer, the titer value is 12800.

Clinical research

Neutralizing antibody titer detection

Product list
LineageCat. No.Product DescriptionPreorder/Order
SARS-CoV-2
Wild Type
RAS-N022Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit

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RAS-N044Anti-SARS-CoV-2 Neutralizing Antibody Quantitative Detection Kit (Spike RBD) Calibrated to the WHO(G, NIBSC code 20/136)

Order

SARS-CoV-2
Alpha
B.1.1.7
RAS-N028Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

Order

SARS-CoV-2
Beta
B.1.351
RAS-N031Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

Order

SARS-CoV-2
Gamma
P.1
RAS-N034Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

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SARS-CoV-2
Delta
B.1.617.2
RAS-N040Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike RBD)

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RAS-N041Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike Trimer)

Order

SARS-CoV-2
Omicron
B.1.1.529
RAS-N056Anti-SARS-CoV-2 (B.1.1.529) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

Order

SARS-CoV-2
Omicron
NEW
BA.2
RAS-N087Anti-SARS-CoV-2 (BA.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

Preorder

>>>Click to find out more solution for neutralization assay: pseudovirus and related service

Assay Data

Anti-SARS-COV-2 Neutralizing Antibody Titer Serologic Assay Kit based on WT RBD (Cat. No. RAS-N022), B.1.1.7 RBD (Cat. No. RAS-N028), B.1.351 RBD (Cat. No. RAS-N031) and P.1 RBD (Cat. No. RAS-N034) are used to detect neutralizing antibodies in 56 post-vaccination serum samples in order to evaluate vaccine efficacy against SARS-CoV-2 Variants of Concerns (VOC).

IgG Antibody Titer Detection

Product list
LineageMoleculeCat. No.Product DescriptionPreorder/Order
SARS-CoV-2
wild type
Spike proteinRAS-T048Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike Trimer) Calibrated to the WHO(G, NIBSC code 20/136)

Order

Spike RBDRAS-T049Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike RBD) Calibrated to the WHO(G, NIBSC code 20/136)

Order

Spike RBDRAS-T024Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Order

Spike proteinRAS-T025Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

Order

Spike S1RAS-T001Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

Order

Nucleocapsid ProteinRAS-T008Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein)

Order

SARS-CoV-2
Alpha
B.1.1.7
Spike RBDRAS-T026Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Order

Spike proteinRAS-T027Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Protein)

Order

SARS-CoV-2
Beta
B.1.351
Spike RBDRAS-T029Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Order

Spike proteinRAS-T030Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Protein)

Order

SARS-CoV-2
Gamma
P.1
Spike RBDRAS-T032Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Order

Spike proteinRAS-T033Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Protein)

Order

SARS-CoV-2
Delta
B.1.617.2
Spike RBDRAS-T042Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Order

Spike proteinRAS-T043Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

Order

SARS-CoV-2
Omicron
B.1.1.529
Spike RBDRAS-T057Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

Order

Spike proteinRAS-T058Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer))

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>>>Click to find out more ELISA kits for IgM/ Total antibody detection

Assay Data

Cat.No. RAS-T024 can accurately test the antibody titer in vaccinated serum. The batch-to-batch difference and precision were all less than 10%.

Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike Trimer) (Cat.No. RAS-T048) is developed for quantitative detection of IgG antibodies in post-vaccination serum. This kit is an important supplement to the existing vaccine evaluation methods which significantly improve the efficiency and accuracy of vaccine evaluation.

ADE/VED study

Product list
LineageMoleculeCat. No.SampleProduct DescriptionPreorder/Order
SARS-CoV-2
Wild Type
IgG1RAS-T014Human SerumAnti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay kit

Order

IgG2RAS-T015Human SerumAnti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay kit

Order

IgG3RAS-T016Human SerumAnti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay kit

Order

IgG4RAS-T017Human SerumAnti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay kit

Order

SARS-CoV-2        Omicron (B.1.1.529)IgG1RAS-T065Human SerumAnti-SARS-CoV-2 (B.1.1.529) Antibody IgG1 Titer Serologic Assay Kit (Spike RBD)

Order

IgG2RAS-T066Human SerumAnti-SARS-CoV-2 (B.1.1.529) Antibody IgG2 Titer Serologic Assay Kit (Spike RBD)

Preorder

IgG3RAS-T067Human SerumAnti-SARS-CoV-2 (B.1.1.529) Antibody IgG3 Titer Serologic Assay Kit (Spike RBD)

Order

IgG4RAS-T068Human SerumAnti-SARS-CoV-2 (B.1.1.529) Antibody IgG4 Titer Serologic Assay Kit (Spike RBD)

Preorder

>>>Click to find out more ELISA kits for IgM/ Total antibody detection

Assay Data

cross-validation data for antibody subtype detection

>>> If you have any customized inquiries or suggestions for SARS-CoV-2 (COVID-19) related product development, please click here.

>>> Any custom requests, suggestions or feedback are welcome. click here.

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