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> Isotype Controls: Revealing Non-Specificity in Drug Development 
In the intricate journey of drug development, ensuring the accuracy and reliability of experimental results is essential. Isotype controls, being counterparts to the drug of interest that share the same species, origin, class and subtypes, yet lack the capacity for specific antigen binding, structurally mimic potential non-specific binding or background signals. They serve as invaluable tools to assist researchers in distinguishing genuine specific signals from non-specific noise. The selection and use of suitable isotype control products can greatly contribute to minimizing false positives, optimizing experimental conditions, and validating drug specificity, thereby providing robust support throughout the drug development process, from target validation to drug screening and efficacy assessment.
ACROBiosystems offers a comprehensive range of isotype control products such as IgG antibody isotype controls, recombinant IgG Fc proteins, and recombinant serum albumin. These products empower drug research and development with more precise and reliable data support, ensuring the highest standards of accuracy and confidence in every step of the process.
Hapten antibodies exhibit a fully intact IgG structure, covering Human and Mouse species with diverse subtypes and Fc region mutants. Each product undergoes strict quality control measures to ensure high specificity and reproducibility. Serving as validated isotype controls, they are suitable for use in FACS applications.
Only contain the hinge region, CH2, CH3 sequence, ensuring no specific binding with target antigens. As such, they serve as ideal isotype controls for monoclonal antibodies, IgG-like bispecific antibodies, ADCs, and IgG Fc fusion proteins. We also offer IgG Fc mutants for you to explore specific functions in drug development.
Human serum albumin (HSA) stands out for its non-glycosylated nature, stability, and biocompatibility, qualities that render it an exceptional choice as a drug carrier. Our recombinant HSA products, validated by FcRn binding, mimic natural HSA, offering reliable reference standards for HSA fusion proteins drug development as isotype controls.
> Learn more about ComboX, a combination of universal solutions
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