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SPR /BLI analytical service

Biomolecular interaction analysis is used increasingly in drug development to kinetically characterize binding events of relevant components, including drugs and targets, antibodies and antigens or any pair of interacting molecules. Based on the Biacore T200/8K/S200 and ForteBio Octet platforms, ACROBiosystems provides biopharmaceutical R&D customers with complementary molecular interaction analysis services, including antibody screening, characterization, consistency evaluation, and biomolecule interactions that contribute to therapeutics development.

Platforms
Surface Plasmon Resonance (SPR) service
Biacore 8K
Biacore T200
Surface Plasmon Resonance (SPR) technology is the leader and standard in the field of biomolecular interactions. SPR technology can provide unique insights to reveal the interaction between biomolecules, and help scientists understand the function of biomolecules.
Biolayer Interferometry (BLI) service
ForteBio Octet 96e
Biolayer Interferometry (BLI) technology can implement the quantitative and qualitative analysis of intermolecular affinity with the advantages of high sensitivity, high throughput and low sample volume.
ACROBiosystems can provide custom solutions to meet your following needs!
Promotion
Fast and reliable services-Supporting full-cycle of drug development

Promotion period: April.1-August.31,2021
           ACRO proteins supplied free
           Only provide samples to get service completed

The total solution for antibody and Fc receptor affinity testing

All Fc receptor proteins needed are free of charge
           Only provide analytes, then get the full service

 

Case study
Antibody screening/characterization/ bioequivalence evaluation

Anti- BCMA antibodies (Mouse IgG1) captured on CM5 chip via anti-Mouse IgG antibodies, can bind to Human BCMA Protein, His Tag (Cat. No. BCA-H522y) as determined using a SPR (Biacore T200).

Bispecific T-cell Engager (CD3×BCMA) immobilized on CM5 Chip can bind Human CD3E&CD3D Heterodimer Protein, His Tag&Tag Free (Cat. No. CDD-H52W1) with an affinity constant of 31.8 nM as determined in a SPR assay (Biacore T200).

Bispecific T-cell Engager (CD3×BCMA) immobilized on CM5 Chip can bind Human CD3E&CD3D Heterodimer Protein, His Tag&Tag Free (Cat. No. CDD-H52W1) with an affinity constant of 31.8 nM as determined in a SPR assay (Biacore T200).

Batch consistency of Human Fc gamma RIIB / CD32b (Cat. No. CDB-H5228). The similarity of Human Fc gamma RIIB / CD32b (Cat. No. CDB-H5228) for different batches is more than 90% (Biacore T200).

Fc receptor proteins/complement affinity assay

Bispecific antibody (BsAb-IgG)binding with Fc gamma Receptor

The affinity between different IgG antibody subtypes and Human FcRn Protein (Cat.No.FCM-H82W4)

Large molecules affinity testing

IL-15 (Cat. No. IL5-H52H8) binding with IL-2 R beta with an affinity constant of 0.21 nM as determined in a SPR assay(Biacore T200).

Human ACE2 Protein, Fc Tag (Cat. No. AC2-H5257) binding with SARS-CoV-2 S protein RBD (W436R), His tag (Cat. No. SPD-S52H7) with an affinity constant of 6.96 nM as determined in a SPR assay (Biacore T200).

Small molecule affinity testing

SARS-CoV-2 3CL-Mpro, His Tag immobilized on CM5 Chip can bind to Dipyridamole with an affinity constant of 65.1 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Advantage
  1. ● Comprehensive protein products

  2. ● Professional R&D technical team

  3. ● Next day reports at the earliest

  4. ● Data quality meets filing requirement

  5. ● High standard quality management control system

  6. ● Multi-testing platforms (Newark, US; Beijing and Nanjing, China)

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