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Neuraminidase (NA)

Brief Information

Target Synonym:Neuraminidase
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Synonym Name



Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Peramivir Hydrate JNJ-2; BCX-1812; S-021812; RWJ-270201 Approved Biocryst Pharmaceuticals 力纬, Alpivab, Rapivab, Rapiacta, Peramiflu United States Influenza, Human Biocryst Pharmaceuticals Inc 2010-01-13 Cough; Headache; Myalgia; Musculoskeletal Pain; Fatigue; Influenza, Human; Fever; Arthralgia; Nasal Obstruction; Pharyngitis Details
Oseltamivir Phosphate GS-4104; EN-241104; RO-640796; Ro-64-0796; GS-4104-002; GS-4104/002; RO-640796/002 Approved F. Hoffmann-La Roche Ltd 达菲, Tamiflu, Hanmi Flu EU Influenza, Human Roche Registration Gmbh 1999-09-21 Influenza, Human; Kidney Failure, Chronic Details
Zanamivir GG-167; GR-121167; GR-121167X; 4-Guanidino-Neu5Ac2en Approved Glaxosmithkline Plc 依乐韦, Relenza EU Influenza, Human Glaxosmithkline Trading Services Ltd 1999-07-26 Orthomyxoviridae Infections; Influenza, Human Details
Laninamivir Octanoate Hydrate CS-8958; R-118958 Approved Daiichi Sankyo Co Ltd Inavir Japan Influenza B virus infection; Influenza A virus infections Daiichi Sankyo Co Ltd 2010-09-10 Influenza A virus infections; Influenza, Human; Asthma; Influenza B virus infection Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Oseltamivir/Pimodivir Phase 1 Clinical Johnson & Johnson Influenza A virus infections Details
HNC042 HNC-042 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Influenza A virus infections; Influenza, Human; Influenza B virus infection Details

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