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Your Position: Home > LRP-6

LRP-6

Brief Information

Name:Low-density lipoprotein receptor-related protein 6
Target Synonym:LDL Receptor Related Protein 6,LRP6
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
LR6-H82E7 Human Biotinylated Human LRP-6 (20-630) Protein, His,Avitag™
LR6-H82E7-structure
LR6-H82E7-sds
LR6-H5253 Human Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag
LR6-H5253-structure
LR6-H5253-sds
ACRO Quality

Part of Bioactivity data

LR6-H5253-ELISA
LRP-6 ELISA

Immobilized Mouse Dkk-1, His Tag (Cat. No. DK1-M52H6) at 5 μg/mL (100 μL/well) can bind Human LRP-6 (20-630), Mouse IgG2a Fc Tag (Cat. No. LR6-H5253) with a linear range of 10-78 ng/mL (QC tested).

Protocol
LR6-H82E7-ELISA
LRP-6 ELISA

Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 1 μg/mL (100 μL/well) can bind Biotinylated Human LRP-6, His,Avitag (Cat. No. LR6-H82E7) with a linear range of 1-39 ng/mL (QC tested).

Protocol

Synonym Name

LRP-6,LRP6

Background

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

Clinical and Translational Updates

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