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Your Position: Home > VEGF-C

VEGF-C

Brief Information

Name:Vascular endothelial growth factor C
Target Synonym:Vascular Endothelial Growth Factor-Related Protein,Flt4-L,VRP,FLT4 Ligand DHM,LMPH1D,VEGF-C,Vascular Endothelial Growth Factor C,Flt4 ligand,VEGFC,LMPHM4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
VEC-H4225 Human Human VEGF-C / Flt4-L Protein, His Tag
VEC-H4225-structure
VEC-H4225-sds
VEC-H4225-elisa_1
VEC-H4225-elisa_2

Part of Bioactivity data

VEC-H4225-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human VEGF-C, His Tag (Cat. No. VEC-H4225) captured on CM5 Chip via anti-His antibody can bind Human VEGF R3, Fc Tag (Cat. No. FL4-H5251) with an affinity constant of 41.1 pM as determined in SPR assay (Biacore T200) (Routinely tested).

VEC-H4225-ELISA
Human VEGF-C, His TagHuman VEGF-C, His Tag (Cat. No. VEC-H4225) ELISA bioactivity

Immobilized Human VEGF R3, Fc Tag (Cat. No. FL4-H5251) at 5 μg/mL (100 μL/well) can bind Human VEGF-C, His Tag (Cat. No. VEC-H4225) with a linear range of 2-20 ng/mL (QC tested).

Synonym Name

VEGFC,Flt4-L,VRP

Background

Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VEGF-C gene therapy (Herantis Pharma) LX-1101; Ad-VEGF-C Phase 2 Clinical Herantis Pharma Lymphedema Details
OPT-302 OPT-302; VGX-300 Phase 3 Clinical Orphan Europe Sarl Neovascularization, Pathologic; Retinal Diseases; Diabetic macular oedema; Retinal Degeneration; Macular Degeneration Details

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