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EGF R

EGF R Molecule Information

Name:Epidermal growth factor receptor erbB1
Target Synonym:EC:2.7.10.1,EC 2.7.10,Receptor tyrosine-protein kinase erbB-1,Proto-oncogene c-ErbB-1,Epidermal growth factor receptor,EGFR,Erb-B2 Receptor Tyrosine Kinase 1,ERBB1,ERBB,HER1,Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian),Avian Erythrobla
Number of Launched Drugs:30
Number of Drugs in Clinical Trials:127
Lastest Research Phase:Phase 3 Clinical

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EGF R Part of Bioactivity data

EGR-H82E3-Cell-based assay
Evaluation of CAR expression

Cells were transfected with anti-EGFR scFv and cultured for 3 days. Three days post-transfection, 1e6 cells were stained for anti-EGFR scFv with Biotinylated Human EGFR, His,Avitag (Cat. No. EGR-H82E3) followed by PE-conjugated streptavidin. Flow Cytometry assay shows that Biotinylated Human EGFR, His,Avitag (Cat. No. EGR-H82E3) can bind to cells expressing anti-EGFR scFv. The concentration of EGFR used is 0.8 µg/mL. (Data are kindly provided by Guangzhou Bio-gene Technology Co. Ltd.)

EGR-H522a-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Erbitux on CM5 Chip via anti-human Fc IgG, can bind Human EGF R, His Tag, low endotoxin (Cat.No. EGR-H522a) with an affinity constant of 0.492 nM as determined in SPR assay (Biacore T200) ( Routinely tested).

EGR-M5224-SPR
Human_FcRn_Heterodimer_Protein_SPR

Captured Mouse EGF R, His Tag (Cat. No. EGR-M5224) on CM5 Chip via anti-His antibody can bind Mouse EGF, Fc Tag (Cat. No. EGF-M5265) with an affinity constant of 5.44 nM as determined in SPR assay (Biacore T200) (Routinely tested).

EGF R Molecule Synonym Name

EGFR,ERBB,ERBB1,HER1,PIG61,mENA

EGF R Molecule Background

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

EGF R References

EGF R Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Cetuximab biosimilar (CinnaGen) Approved Cinnagen Iran Colorectal Neoplasms s:8:"Cinnagen"; 2017-01-01 Colorectal Neoplasms Details
Olmutinib ZL-2303; HM-61713; HM-61713B; BI-1482694 Approved Hanmi Pharmaceutical Co Ltd Olita South Korea Carcinoma, Non-Small-Cell Lung s:27:"Hanmi Pharmaceutical Co Ltd"; 2016-05-01 Carcinoma, Non-Small-Cell Lung Details
Recombinant epidermal growth factor (Shanghai Haohai ) Approved Shanghai Haohai Biological Technology Co Ltd 康合素 Mainland China Burns s:44:"Shanghai Haohai Biological Technology Co Ltd"; 2001-01-01 Burns Details
Cetuximab sarotalocan RM-1929; ASP-1929 Approved Aspyrian Therapeutics Akalux Japan Head and Neck Neoplasms s:15:"Rakuten Medical"; 2020-09-25 Head and Neck Neoplasms Details
Dacomitinib PF-299; PF-804; PF-299804; PF-00299804; PF-00299804-3; PF-00299804-03 Approved Pfizer Inc Vizimpro Mainland China Carcinoma, Non-Small-Cell Lung s:21:"Pfizer Europe Ma Eeig"; 2018-09-27 Head and Neck Neoplasms; Solid tumours; Neoplasms; Liver Diseases; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Neratinib Maleate CAN-030; PB-272; HKI-272; PF-0528767; WAY-179272 Approved Pfizer Pharmaceuticals Ltd (China) Nerlynx Mainland China Breast Neoplasms s:20:"Excella Gmbh & Co Kg"; 2017-07-17 Solid tumours; Breast Neoplasms; Hepatic Insufficiency; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Panitumumab ABX-0303; E7.6.3; AMG-954; ABX-EGF; ABX-10221 Approved Amgen Inc Vectibix Japan Colorectal Neoplasms s:6:"Takeda"; 2006-09-27 Solid tumours; Head and Neck Neoplasms; Carcinoma; Carcinoma, Renal Cell; Rectal Neoplasms; Esophageal Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Lung Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Erlotinib Hydrochloride R-1415; OSI-774; RG-1415; CP-358774; NSC-718781; RO-0508231; CP-358774-01 Approved Genentech Inc 特罗凯, Tarceva Japan Carcinoma, Non-Small-Cell Lung s:28:"Chugai Pharmaceutical Co Ltd"; 2004-11-18 Head and Neck Neoplasms; Ependymoma; Solid tumours; Pancreatic Neoplasms; Glioblastoma; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Nimotuzumab h-R3; DE-766; KI-0501; KI-0502; OSAG-10; OSAG-101; YMB-1000; TheraCIMh-R3 Approved Center Of Molecular Immunology 泰欣生, CIMAher, TheraCIM, Theraloc, BIOMAb-EGFR Mainland China Nasopharyngeal Neoplasms s:30:"Biotech Pharmaceuticals Co Ltd"; 2006-07-21 Head and Neck Neoplasms; Pancreatic Neoplasms; Nasopharyngeal Neoplasms; Carcinoma, Squamous Cell; Glioma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Cetuximab C-255; ch-225; IMC-C255; BMS-564717; EMD-271786; GT-MAB-5.2; LY-2939777; NSC-714692 Approved Bristol-Myers Squibb Company, Eli Lilly And Company, Merck Serono 爱必妥, Erbitux Japan Colorectal Neoplasms; Head and Neck Neoplasms s:12:"Merck Serono"; 2004-02-12 Head and Neck Neoplasms; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Lapatinib Ditosylate Hydrate GW-2016; GW-572016; GW-572016F Approved Novartis Pharma Ag, Glaxosmithkline Plc Tykerb/Tyverb, 泰立沙, Tykerb, Tyverb Mainland China Breast Neoplasms s:18:"Glaxosmithkline Ag"; 2007-03-13 Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Breast Diseases; Glioma; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Alflutinib Mesylate AST-2818 Approved Shanghai Allist Pharmaceutical Technology Co Ltd 艾弗沙 Mainland China Carcinoma, Non-Small-Cell Lung s:48:"Shanghai Allist Pharmaceutical Technology Co Ltd"; 2021-03-02 Carcinoma, Non-Small-Cell Lung Details
Gefitinib ZD-1839 Approved Astrazeneca Pharmaceutical Co Ltd 易瑞沙, Iressa EU Carcinoma, Non-Small-Cell Lung s:14:"Astrazeneca Ab"; 2002-07-05 Head and Neck Neoplasms; Carcinoma; Small Cell Lung Carcinoma; Glioblastoma; Mesothelioma; Prostatic Neoplasms; Breast Neoplasms; Brain Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Squamous Cell; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Afatinib Dimaleate BIBW-2992; BIBW-2992-MA2 Approved C.H. Boehringer Sohn Ag & Co. Kg 吉泰瑞, Tovok, Giotrif, Gilotrif, Tomtovok Mainland China Carcinoma, Non-Small-Cell Lung s:39:"Boehringer Ingelheim International Gmbh"; 2013-07-12 Head and Neck Neoplasms; Rhabdomyosarcoma; Squamous Cell Carcinoma of Head and Neck; Renal Insufficiency; Neoplasms; Neuroectodermal Tumors; Liver Diseases; Endometriosis; Breast Neoplasms; Colorectal Neoplasms; Urologic Neoplasms; Carcinoma, Squamous Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Brigatinib AP-26113 Approved Takeda Pharmaceutical Co Ltd, Ariad Alunbrig Japan Carcinoma, Non-Small-Cell Lung s:6:"Takeda"; 2017-04-28 Solid tumours; Carcinoma; Myofibroma; Lymphoma, Large-Cell, Anaplastic; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Necitumumab IMC-11F8; LY-3012211 Approved Eli Lilly And Company Portrazza Japan Carcinoma, Non-Small-Cell Lung s:20:"Nippon Kayaku Co Ltd"; 2015-11-24 Solid tumours; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Vandetanib CH-331; ZD-6474; AZD-6474 Approved Astrazeneca Pharmaceutical Co Ltd Zactima, Caprelsa Japan Medullary thyroid cancer (MTC) s:33:"Astrazeneca Pharmaceutical Co Ltd"; 2011-04-06 Solid tumours; Multiple Myeloma; Mesothelioma; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Thyroid Neoplasms; Lung Neoplasms; Carcinoma, Neuroendocrine; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Osimertinib Mesylate AZD9291; AZD-9291; RDL94R2A16; AZD-9291 Mesylate Approved Astrazeneca Pharmaceutical Co Ltd 泰瑞沙, Tagrisso Mainland China Carcinoma, Non-Small-Cell Lung s:14:"Astrazeneca Ab"; 2015-11-13 Solid tumours; Carcinoma; Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Mouse epidermal growth factor (Hangzhou Tianmushan Pharmaceutical) Approved Hangzhou Tianmushan Pharmaceutical Enterprise Co Ltd 一夫 N; Wounds and Injuries Details
Pyrotinib Maleate HTI-1001; SHR-1258; BLTN Approved Jiangsu Hengrui Medicine Co Ltd 艾瑞妮 Mainland China Breast Neoplasms s:31:"Jiangsu Hengrui Medicine Co Ltd"; 2018-08-12 Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant epidermal growth factor drop (Pavay Gene Pharmaceutical) Approved Guilin Huanuowei Gene Pharmaceutical Co Ltd 易贝 Mainland China Corneal Diseases s:43:"Guilin Huanuowei Gene Pharmaceutical Co Ltd"; 2002-04-12 Corneal Diseases; Xerophthalmia Details
Almonertinib Mesilate HS-10296 Approved Jiangsu Hansoh Pharmaceutical Group Co Ltd 阿美乐 Mainland China Carcinoma, Non-Small-Cell Lung s:42:"Jiangsu Hansoh Pharmaceutical Group Co Ltd"; 2020-03-17 Carcinoma, Non-Small-Cell Lung Details
Recombinant Human Epidermal Growth Factor Derivative Eye Drops (Shenzhen Wastin Genetech) Approved Shenzhen Watsin Genetech Ltd 金因舒, GeneSoft Mainland China Corneal Diseases s:28:"Shenzhen Watsin Genetech Ltd"; 2004-01-21 Corneal Diseases Details
Recombinant epidermal growth factor biosimilar (Elea) r-hu-EGF Approved Elea Argentina Diabetic Foot; Burns s:4:"Elea"; 2015-01-01 Diabetic Foot; Burns Details
Recombinant epidermal growth factor (Bharat Biotech) REGEN-D 60; REGEN-D 150 Approved Bharat Biotech International Ltd India Diabetic Foot; Burns s:32:"Bharat Biotech International Ltd"; 2005-01-01 Diabetic Foot; Burns Details
Recombinant human EGF conjugated vaccine Approved Biotech Pharmaceutical Co Ltd N; Carcinoma, Non-Small-Cell Lung Details
Icotinib Hydrochloride BPI-2009H; BPI-2009C Approved Betta Pharmaceuticals Co Ltd 凯美纳, Conmana Mainland China Carcinoma, Non-Small-Cell Lung s:28:"Betta Pharmaceuticals Co Ltd"; 2011-06-07 Stomach Neoplasms; Esophageal Neoplasms; Psoriasis; Nasopharyngeal Carcinoma; Esophageal adenocarcinoma; Brain metastases; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Nepidermin DWP-401 Approved Daewoong Pharmaceutical Co Ltd Easyef Egypt Alopecia; Diabetic Foot s:30:"Daewoong Pharmaceutical Co Ltd"; 2001-01-01 Diabetic Foot; Alopecia Details
Recombinant Human Epidermal Growth Factor Derivative For External Use,Liquid (Shenzhen Wastin Genetech) rEGF Approved Shenzhen Watsin Genetech Ltd 金因肽, GeneTime Mainland China Wounds and Injuries s:28:"Shenzhen Watsin Genetech Ltd"; 2001-01-01 Wounds and Injuries Details
Recombinant epidermal growth factor (Center for Genetic Engineering and Biotechnology/Praxis Pharmaceuticals) Approved Center For Genetic Engineering And Biotechnology, Praxis Pharmaceuticals Heberprot-P Cuba Diabetic Foot s:4:"null"; 2007-09-01 Diabetic Foot Details
Recombinant epidermal growth factor gel (Pavay Gene Pharmaceutical) Approved Guilin Huanuowei Gene Pharmaceutical Co Ltd 易孚 Mainland China Skin Ulcer; Burns s:43:"Guilin Huanuowei Gene Pharmaceutical Co Ltd"; 2002-12-23 Skin Ulcer; Burns Details
Epidermal growth factor biosimilar (RAS Lifesciences) Approved Ras Lifesciences India s:16:"Ras Lifesciences"; 2012-10-01 Details

EGF R Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JMT101 JMT-101 Phase 1 Clinical Shanghai Jinmante Biological Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
BBT-176 BBT-176 Phase 2 Clinical Bridge Biotherapeutics Carcinoma, Non-Small-Cell Lung Details
Durvalumab/Gefitinib Phase 2 Clinical Medimmune Carcinoma, Non-Small-Cell Lung Details
Cetuximab biosimilar (Enzene Biosciences) Clinical Enzene Biosciences Carcinoma, Squamous Cell Details
Neptinib Di-P-methylbenzenesulfonate Phase 1 Clinical Shenzhen Neptune Pharmaceutical Technology Research Institute Co Ltd Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Pirotinib Hydrochloride KBP-5209 Phase 2 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
YZJ-0318 Maleate YZJ-0318 Maleate Phase 1 Clinical Shanghai Haiyan, Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceut Co Ltd Carcinoma, Non-Small-Cell Lung Details
Recombinant anti-EGFR chimeric antibody (Harbin Pharmaceutical) Phase 1 Clinical Harbin Pharmaceutical Group Holding Co Ltd Colorectal Neoplasms Details
BCA-101 BCA-101 Phase 1 Clinical Bicara Therapeutics Anus Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Carcinoma, Anaplastic; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Neoplasms; Uveal melanoma; Chordoma; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Hepatocellular Details
EGFRvIII-CAR Phase 1 Clinical Duke University Medical Center Glioblastoma Details
Recombinant anti-EGFR monoclonal antibody (Humanwell Healthcare) Phase 1 Clinical Humanwell Healthcare (Group) Co Ltd Colorectal Neoplasms Details
C-005 C-005 Phase 1 Clinical Nanjing Galaxy Biopharma Co Ltd Carcinoma, Non-Small-Cell Lung Details
Anti-EGFR CAR-T cell therapy (Cellular Biomedicine Group) Phase 2 Clinical Cellular Biomedicine (Shanghai) Co Ltd, People'S Liberation Army General Hospital Military Service Neoplasms Details
Anti-CD3/anti-EGFR -activated T cells (Barbara Ann Karmanos Cancer Institute) Phase 2 Clinical Barbara Ann Karmanos Cancer Institute, University Of Virginia Glioblastoma; Pancreatic Neoplasms Details
Anti-EGFR-IL-dox (Swiss Group for Clinical Cancer Research) Phase 2 Clinical Schweizerische Arbeitsgemeinschaft Für Klinische Krebsforschung Breast Neoplasms Details
BB-101 (Blue Blood Biotech/National Cheng Kung University) BB-101 Phase 1 Clinical National Cheng Kung University, Blue Blood Biotech Diabetic Foot Details
NRC-2694 NRC-2694; NRC-2694A; NRC-2694-A Phase 2 Clinical Natco Carcinoma, Squamous Cell Details
Autologous EGFR-CAR T cells (Bio-gene) Phase 1 Clinical Sun Yat-Sen University, Guangzhou Baiji Gene Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Tarloxotinib Bromide PR-610; TH-4000; SN-33999 Phase 2 Clinical Threshold Neoplasms; Carcinoma, Non-Small-Cell Lung Details
C225-ILS-DOX C225-ILs-dox Phase 2 Clinical Universitaetsspitals Basel Breast Neoplasms Details
E-EDV-D682 PNU-15982; E-EDV-D682; EGFR-EDV-PNU-15982 Phase 2 Clinical Engeneic Pancreatic Neoplasms Details
MicroRNA encapsulated nanocells (EnGeneIC) Phase 2 Clinical Engeneic Mesothelioma Details
AFM-24 AFM-24 Phase 2 Clinical Affimed Neoplasms Details
Cetuximab biosimilar (R-Pharm) RPH-002 Phase 3 Clinical R-Pharm Head and Neck Neoplasms; Pancreatic Neoplasms Details
14C-labeled poziotinib Phase 1 Clinical Spectrum Pharmaceuticals Neoplasms Details
Cetuximab biosimilar (AlphaMab) KN-005 Phase 3 Clinical Suzhou Alphamab Co Ltd Head and Neck Neoplasms; Anus Neoplasms; Urinary Bladder Neoplasms; Colorectal Neoplasms Details
AMX-3009 Maleate AMX-3009; AMX3009马来酸 Phase 1 Clinical Anrun Medicine Technology (Suzhou) Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Breast Neoplasms Details
4-1BBz CD19-Her2tG (Seattle Children's Hospital) Phase 1 Clinical Seattle Children'S Hospital Neoplasms Details
Cetuximab biobetter (Glycotope) GT-MAB-5.2-GEX Phase 2 Clinical Glycotope Head and Neck Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Anti-EGFR-bispecific antibody armed activated T-cell therapy (Memorial Sloan Kettering Cancer Center) Phase 1 Clinical Memorial Sloan Kettering Cancer Center Pancreatic Neoplasms Details
HER-1 vaccine (Center of Molecular Immunology) HER1-ECD; HER1-VSSP; HER-1-ECD-VSSP Phase 2 Clinical Center Of Molecular Immunology Neoplasms Details
Double-deleted Vaccinia Virus Plus CD/ SMR JX-929; vvDD-CDSR Phase 1 Clinical Sillajen Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Melanoma Details
SGT-210 SGT-210 Phase 1 Clinical Sol Gel Technologies Pte Ltd Keratosis Details
Futuximab/Modotuximab Sym-004; 992-and-1024 Phase 3 Clinical Symphogen Carcinoma; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms Details
Pemlimogene merolisbac (Aduro Biotech/Jannsen Biotech) ADU-214; JNJ-64041757 Phase 2 Clinical Aduro Biotech Ovarian Neoplasms; Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung Details
MM-151 MM-151 Phase 2 Clinical Merrimack Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
EMB-01 EMB-01 Phase 2 Clinical Shanghai Epimab Biotherapeutics, Inc Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
D2C7-based immunotoxins (Duke University) D2C7-IT; scds-D2C7 -PE38KDEL; D2C7-(scdsFv)-PE38 KDEL Phase 1 Clinical Istari Oncology, Duke University Glioma Details
PB-357 PB-357 Phase 1 Clinical Pfizer Inc Neoplasms Details
Losatuxizumab vedotin ABBV221; ABBV-221 Phase 1 Clinical Abbvie Inc Neoplasms Details
Nimotuzumab biosimilar (El Kendi Pharmaceuticals Manufacturing) Phase 3 Clinical El Kendi Pharmaceuticals Uterine Cervical Neoplasms Details
TQB3804 TQB-3804 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Solid tumours; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Recombinant anti-EGFR monoclonal antibody- DUO5 conjugate Phase 1 Clinical Zhejiang Hisun Pharmaceutical Co Ltd, Zhejiang Zhaohua Biomedicine Co Ltd Neoplasms Details
SI-B001 SI-B001 Phase 1 Clinical Sichuan Baili Pharmaceutical Co Ltd Carcinoma; Neoplasms, Glandular and Epithelial Details
BB-401 BB-401 Phase 2 Clinical Benitec Biopharma Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck Details
WSD-0922 WSD0922; WSD-0922 Phase 1 Clinical Wayshine Biopharm Glioblastoma; Glioma Details
Doxitinib mesylate Phase 2 Clinical Henan Real Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Cetuximab biobetter (Mabtech/Sorrento) STI-001 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd, Shanghai Biomabs Pharmaceuticals Co Ltd Colorectal Neoplasms Details
Anti-EGFR CAR T-cell therapy (Seattle Children's Hospital) EGFR-806 Phase 1 Clinical Seattle Children'S Hospital Central Nervous System Neoplasms Details
Epertinib S-222611 Phase 2 Clinical Shionogi & Co Ltd Neoplasms Details
BEBT-109 BEBT-109 Phase 1 Clinical Guangzhou Bibet Medical Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
KSP-QRH-E3-IRDye800 Phase 1 Clinical University Of Michigan Cholangiocarcinoma Details
YK-029A YK-029A Phase 1 Clinical Hainan Yuekang Biomedicine Co Ltd Carcinoma, Non-Small-Cell Lung Details
Entinostat/Erlotinib Hydrochloride Phase 2 Clinical Colorado State University Foundation, Syndax Carcinoma, Non-Small-Cell Lung Details
MP-0274 DARPin-41; SPA-28; CME-114; CME-115; CME-118; CME-119; MP-0274 Phase 1 Clinical Molecular Partners Ag Neoplasms Details
DZD-9008 DZD-9008 Phase 2 Clinical Dizal (Jiangsu) Pharmaceutical Co Ltd Leukemia; Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung Details
ZSP0391 ZSP-0391 Phase 1 Clinical Wuxi Apptec Co Ltd, Guangdong Zhongsheng Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details
Antibody-drug nanocell conjugates (EnGeneIC) EGFR-EDV-RRM1; EGFR-EDV-PLK; EGFR-EDV-Dox Phase 1 Clinical Engeneic Glioblastoma Details
Humanized anti-EGFR monoclonal antibody (Shanghai Henlius Biotech) HLX-07 Phase 2 Clinical Shanghai Henlius Biotech Co Ltd Squamous Cell Carcinoma of Head and Neck; Neoplasms Details
Sirotinib Maleate XZP-5491 Phase 1 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Stomach Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Cetuximab I-131 (Pacific Meinuoke) Clinical Jiangsu Pacific-Meinuoke Bio-Pharmaceutical Co Ltd Colorectal Neoplasms Details
Panitumumab-IRDye800CW (Stanford University) Phase 2 Clinical Stanford University Brain Neoplasms Details
Cimaglermin alfa CGF-2 Phase 1 Clinical Ludwig Institute For Cancer Research Heart Failure Details
Humanized anti-EGFR monoclonal antibody (Hualan Biological Engineering/Henan shengming biotechnology) Phase 1 Clinical Hualan Genetic Engineering Co Ltd, Henan Shengming Biotechnology Research Institute Co Ltd Colorectal Neoplasms Details
ABY-029 ABY-029 Phase 1 Clinical Dartmouth College, Affibody, Li-Cor Bioscience Glioma Details
DBPR-112 DBPR-112 Phase 1 Clinical National Health Research Institutes Head and Neck Neoplasms; Lung Neoplasms Details
普维替尼 Phase 1 Clinical Suzhou Teligene Ltd Neoplasms Details
Cetuximab biosimilar (Shanghai Henlius Biotech) HLX-05 Phase 1 Clinical Shanghai Henlius Biotech Co Ltd Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms Details
Recombinant human anti-EGFR mAb (Serum Biotechnology) SY-101 Phase 2 Clinical Institute Of Bioengineering Chinese Academy Of Military Medical Sciences, Shanghai Sailun Biological Technology Co Ltd Colorectal Neoplasms Details
BDTX-189 BDTX-189 Phase 2 Clinical Black Diamond Therapeutics Neoplasms Details
Recombinant chimeric anti-EGFR monoclonal antibody (Zhejiang Xinwei Shengke Biotechnology) Phase 1 Clinical Zhejiang Xinweishengke Biotechnology Co Ltd Esophageal Neoplasms Details
Cetuximab biosimilar (Kelun Group) KLA140; KL-A140 Phase 3 Clinical Sichuan Kelun Pharmaceutical Co Ltd Colorectal Neoplasms Details
Tesevatinib KD-019; KD-020; XL-647; EXEL-7647 Phase 3 Clinical Exelixis Inc Glioblastoma; Breast Neoplasms; Brain Neoplasms; Polycystic Kidney, Autosomal Dominant; Brain metastases; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Polycystic Kidney, Autosomal Recessive Details
TQB3456 TQB-3456 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd, Beijing Sailintai Medicine Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
SPH1188-11 SPH1188-11 Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
GC-1118A GC-1118; GC-1118A Phase 2 Clinical Korean Green Cross Corp Stomach Neoplasms; Glioblastoma; Colorectal Neoplasms; Neoplasm Metastasis Details
Epitinib Succinate HMPL-813 Phase 1 Clinical Hutchison Medipharma Ltd Solid tumours; Glioblastoma; Carcinoma, Non-Small-Cell Lung Details
ASP-0598 ASP-0598 Phase 2 Clinical Auration Biotech, Astellas Pharma Inc Ear Diseases; Tympanic Membrane Perforation Details
QL1203 QL-1203 Phase 3 Clinical Qilu Pharmaceutical Co Ltd Colorectal Neoplasms Details
Varlitinib Ditosylate QBT-01; ARRY-543; SPS-4370; ASLAN-001; ARRY-334543 Phase 3 Clinical Array Biopharma Biliary Tract Neoplasms; Neoplasms; Pancreatic Neoplasms; Bile Duct Neoplasms Details
M-1231 M-1231 Phase 1 Clinical Emd Serono Research & Development Institute Inc Solid tumours; Esophageal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
AZD-3759 AZD-3759 Phase 3 Clinical Astrazeneca Plc Brain metastases; Carcinoma, Non-Small-Cell Lung Details
Poziotinib NOV1201; HM-78136; HM-78136B; NOV-120101 Phase 2 Clinical Hanmi Pharmaceutical Co Ltd Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung Details
TAS-6417 CLN-081; TAS-6417 Phase 2 Clinical Taiho Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
Lazertinib GNS-1480; JNJ-1937; YH-25448; JNJ-73841937 Phase 3 Clinical Genosco Carcinoma, Non-Small-Cell Lung Details
TY-9591 TY-9591 Phase 1 Clinical Zhejiang Tongkang Medicine Co Ltd Carcinoma, Non-Small-Cell Lung Details
Recombinant anti-InE monoclonal antibody Phase 1 Clinical Dingfu Biotarget Solid tumours Details
AP-32788 TAK-788; AP-32788 Phase 3 Clinical Takeda Pharmaceutical Co Ltd, Ariad Pharmaceuticals Inc, Millennium Pharmaceuticals Inc Kidney Diseases; Hepatic Insufficiency; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ES-072 ES-072 Phase 1 Clinical Zhejiang Bosheng Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
FCN-411 FCN-411 Phase 1 Clinical Shanghai Fosun Industry Co Ltd Carcinoma, Non-Small-Cell Lung Details
Anti-EGFR CAR-T cell therapy (Beijing Pregene) Phase 2 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details
ASK-120067 ASK-120067 Phase 3 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Jiangsu Aosaikang Pharmaceutical Co Ltd, Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences Carcinoma, Non-Small-Cell Lung Details
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Colorectal Neoplasms Details
Selatinib Ditosilate QLNC-120 Phase 2 Clinical Qilu Antibiotics (Linyi) Pharmaceutical Co Ltd, Qilu Pharmaceutical Co Ltd Stomach Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
SKLB-1028 SKLB-1028 Phase 3 Clinical Sichuan University, CSPC Pharmaceutical Group Ltd Leukemia, Myeloid, Acute Details
Recombinant human anti-EGFR mAB (Genrix Bio) GR-1401; UBP-1215 Phase 1 Clinical Shanghai Zhonghe Medicine Technology Co Ltd, Bioex Therapeutics Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Allitinib Tosylate AST-6; ALS-1306; AST-1306 Phase 2 Clinical Shanghai Allist Pharmaceutical Technology Co Ltd Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Betatinib TL-512 Phase 1 Clinical Aspedia Llc, Suzhou Teligene Ltd Carcinoma, Non-Small-Cell Lung Details
Recombinant chimeric anti-EGFR monoclonal antibody (Qilu Pharmaceutical) QL-1105 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
Cetuximab biosimilar (AMPO Biotechnology) Phase 3 Clinical Foshan Ampze Biomedicine Co Ltd Colorectal Neoplasms Details
TQ-B3395 TQ-B3395; TQ-B-3395 Phase 1 Clinical Beijing Sailintai Medicine Technology Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Esophageal Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Cetuximab biosimilar (Shanghai Zhangjiang Biotechnology) STI-001; CMAB-009 Phase 3 Clinical Shanghai Zhangjiang Biotechnology Co Ltd Colorectal Neoplasms Details
LR-004 LR-004; SYN-004 Phase 1 Clinical Xingmeng Biotechnology (Beijing) Co Ltd, Lonn Ryonn Pharma Ltd Solid tumours; Lymphoma, Large B-Cell, Diffuse; Colorectal Neoplasms Details
Simotinib Hydrochloride AL-6802; SIM-6802 Phase 1 Clinical Jiangsu Xiansheng Pharmaceutical Co Ltd, Advenchen Laboratories Colonic Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Mefatinib Phase 3 Clinical Suzhou Maitai Bio-Technology Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
CK-101 CK-101; RX-518 Phase 3 Clinical Suzhou Neupharma Co Ltd Lung Diseases; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Yinlitinib Phase 1 Clinical Hec Pharm Co Ltd Solid tumours Details
BPI-15086 BPI-15000; BPI-15086 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details
Cetuximab biosimilar (Guilin Sanjin) CDP-1 Phase 1 Clinical Guilin Sanjin Pharmaceutical Co Ltd, Dragonboat Biopharmaceutical Solid tumours; Colorectal Neoplasms Details
JRF-103 JRF103; JRF-103 Phase 2 Clinical Shenzhen Jinrui Foundation Biotechnology Co Ltd Solid tumours Details
BPI-7711 BPI-7711 Phase 3 Clinical Betapharma (Shanghai) Co Ltd Carcinoma, Non-Small-Cell Lung Details
Depatuxizumab mafodotin ABT-414; ABT-414/806 Phase 3 Clinical Abbvie Inc Glioblastoma; Gliosarcoma; Carcinoma, Squamous Cell; Glioma; Carcinoma, Non-Small-Cell Lung Details
Hemay-020 Hemay-020 Phase 1 Clinical Tianjin Hemei Pharmaceutical Technology Co Ltd, Hainan General Sanyang Pharmaceutical Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Non-Small-Cell Lung Details
SCT-200 SCT-200 Phase 2 Clinical Shenzhou Cell Engineering Co Ltd Ovarian Neoplasms; Biliary Tract Neoplasms; Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Gallbladder Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
HA121-28 HA121-28 Phase 2 Clinical Cspc Pharmaceutical Technology (Shijiazhuang) Co Ltd Biliary Tract Neoplasms; Solid tumours; Esophageal Neoplasms; Medullary thyroid cancer (MTC); Bile Duct Neoplasms Details
[89Zr]Panitumumab (University of Alabama at Birmingham) Phase 2 Clinical University Of Alabama At Birmingham Colonic Neoplasms Details
MRG003 MRG-003 Phase 2 Clinical Shanghai Miracogen Inc Head and Neck Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Sapitinib AZD-8931 Phase 2 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis Details
MCLA-158 MCLA-158 Phase 1 Clinical Merus Colorectal Neoplasms Details
Amivantamab JNJ-61186372; JNJ-372 Phase 3 Clinical Janssen Global Services Llc, Genmab Carcinoma, Non-Small-Cell Lung Details
MCLA-129 MCLA-129 Phase 1 Clinical Merus Solid tumours Details
Larotinib Mesylate Z-650 Phase 3 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Pancreatic Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma Details
Nazartinib EGF-816; EGFRmut-TKI EGF816 Phase 2 Clinical Novartis Pharma Ag Triple Negative Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Oritinib Mesylate SH-1028 Phase 3 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
AVID-100 AVID-100 Phase 2 Clinical Formation Biologics Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Kenaitinib MED-1007; ML-007 Phase 2 Clinical Jiangsu Maidu Pharmaceutical R & D Co Ltd Carcinoma, Non-Small-Cell Lung Details

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