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Your Position: Home > Protein > Mucin-1 > MU1-M52H4

Mouse Mucin-1 / MUC-1 (21-535) Protein, His Tag (SPR verified)

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  • Synonym
    Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin
  • Source
    Mouse Mucin-1 (21-535) Protein, His Tag(MU1-M52H4) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Gly 535 (Accession # Q02496-1).
    Predicted N-terminus: Phe 21
  • Molecular Characterization
    Mucin-1 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 53.9 kDa. The protein migrates as 9 kDa and 65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mucin-1 SDS-PAGE

Mouse Mucin-1 (21-535) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-SPR
 Mucin-1 SPR

Mouse Mucin-1 (21-535) Protein, His Tag (Cat. No. MU1-M52H4) immobilized on CM5 Chip can bind anti-mMUC1-mAb with an affinity constant of 302 nM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
  • Clinical and Translational Updates

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Price(USD) : $350.00

Price(USD) : $2310.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:21 Details
  • Latest Research Phase:Phase 2 Clinical

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