Background
The pipeline of advanced therapy is expanding at a rate never seen before, with a number of cell and gene therapies (CGT) now reaching the market. Continuing advances in CGT are transforming how biopharma companies treat and potentially cure certain diseases.
Cell and gene therapies are the next wave of therapeutic innovation in the life sciences industry. However, the consequent challenges in development, manufacture, quality control, supply chain and commercial affect the whole industry.
As a leading manufacturer of recombinant proteins and other critical reagents to support the development of biomedicine, ACROBiosystems is proud to stand by you in the CGT journey. We employ an application-oriented development strategy, with a particular focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process.
CGT solutions
Early drug discovery
Suitable for immunization, antibody screening and antibody affinity testingMore than 50 targets for solid tumor and blood tumorPE/FITC/Biotin/Unconjugated labeled proteins are availableSome products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA. >>>Find out more Suitable for TCR testing and screeningMonomer and tetramer are available for different applications
High purity verified by SDS-PAGE; High affinity verified by SPR
High stability and batch-to-batch consistency
>>>Find out more Suitable for structure design and gene editionHigh enzyme activity: improve the cutting efficiency to 90% and make it easier to edit gene by CRISPR
High purity verified by SDS-PAGE(＞90%）and SEC-MALS(＞95%）
Bioactivity verified by in-vivo/ in-vitro assay: gene knockout activity in vivo and fragment cleavage activity in vitro
Low endotoxin less than 0.1 EU/ug
High stability and batch-to-batch consistency
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more Manufacture/Quality control
Suitable for cell culture and expansion
（research use and ex vivo cell culture processing only, and is not intended for human in vivo applications）Strict Quality Control Standards: 16 quality control standards and Excellent safety profile. High stability and batch-to-batch consistency.
GMP Grade Quality Management System: ISO 5 cleanrooms used for filling, raw materials and packing materials are registered, and facilities are available for online and on-site audits.
Accelerating Global Regulatory Approval of Biological Products: A comprehensive set of regulatory documents and validation reports are available by request. FDA DMF filing in progress.
>>>Find out more Suitable for nucleic acid removing in Lentivirus purification process and AAV preparation processHigh purity verified by SDS-PAGE and HPLC(> 95%), high specific activity > 1.0 x 106 unit/mgTag Free and close to the natural state, performs a high enzyme activity≥250 U/μlNo protease activity, high specificity and sensitivityBroader reaction conditions: Optimum temperature 35 °C -42 °C, optimum pH 8.0 - 8.5Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.RUO grade products can save the cost in early study; GMP grade products are coming >>>Find out more Recommended for human T cell activation & expansionMicrobial testing and ultra-low endotoxin （＜2 EU/mg）
Efficient activation and expansion
High batch-to-batch consistency
Highly stable and convenient for storage and transportation in lyophilization
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more One-step solution for CAR detection with higher specificity and less processing time, no secondary antibody and non-specific backgroundMore fluoresces are available: FITC/PE/APC, etc.
More advanced technology: use new-generation site-specific labeling technology to maintain natural conformation and modification of the proteins
More stringent quality control standard: High sensitivity and specificity verified by FACS, no non-specific binding to non-transduced PBMCs, high batch-to-batch consistency and stability that meet the requirements of clinical sample analysis
Recommended: More pre-labeled proteins for different applications>>>Find out more Suitable for the quantitative of cytokine in serum and cell matrix（RUO）Self-development based on ACRO’s protein production platform, performance and supply ability and quality assured High sensitivity, specificity and accuracy, strict method validation and quality control to ensure the within-run and between-run precisionEasy to use and high through put, at most 82 samples can be tested at one time in 2 hoursCustomized service and antibodies materials are available Inquiry >>>Find out more Non-clinical studies/Clinical research
Pharmacokinetics (PK) research
Suitable for detecting CAR expression by flow cytometry in preclinical and clinical samplesMore than 50 targets for solid tumor and blood tumorPE/FITC/Biotin labeled proteins are availableHigh stability and batch-to-batch consistency, performs well in flow cytometry in clinical trialsNo non-specific binding to non-transduced PBMCsSome products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA. >>>Find out more Suitable for detecting TCR by flow cytometry in preclinical and clinical trialsMonomer and tetramer are available for different application
High purity verified by SDS-PAGE; High affinity verified by SPR
High stability and batch-to-batch consistency
>>>Find out more Suitable for CAR expression by flow cytometry in preclinical and clinical samplesFeatured anti-FMC63 antibody can specifically recognize the antigen-binding site of FMC63 derived CARs with high affinitySuitable for detecting FMC63 derived anti-CD19 CARs in clinical trialsOvercome the challenges for complex cell components, low CAR-T cell concentration and non-specific background, etc.Fluorescent-labeled products are available for one-step detection, reducing process timeRecommended: FM3-HPY53, FM3-FY45, FM3-BY54 >>>Find out more>>>Anti-Idiotypic Antibody Development Service Immunogenicity evaluation
Suitable for detecting and characteristic of anti-drug antibodiesMonoclonal anti-idiotype antibody, polyclonal anti-idiotype antibody are availableNeutralizing antibodies, suitable for various ADA assay development(Direct/In-direct/Bridge ELISA,RIPA,SPR,Cell-based assay,Competitive Ligand Binding Assay)Recommended products：FM3-S93, FM3-Y45A1 >>>Find out more ACRO provides cell therapy researchers with one-stop services from antigen preparation to polyclonal anti-idiotype antibody and immunogenicity test kit developments.>>>Find out more Pharmacodynamic and safety studies
Suitable for the quantitative of cytokine in serum and cell matrix（RUO）Self-development based on ACRO’s protein production platform, performance and supply ability and quality assured High sensitivity, specificity and accuracy, strict method validation and quality control to ensure the within-run and between-run precisionEasy to use and high through put, more than 82 samples can be tested at one time in 2 hrsCustomized service and antibodies materials are availableInquiry >>>Find out more PRODUCT LIST
| Molecule | Cat. No. | Product Description | Preorder/Order |
|---|
| BCMA | BCA-HF2H3 | FITC-Labeled Human BCMA / TNFRSF17 Protein, His Tag Star Staining | Order |
| CD19 | CD9-HF2H3 | FITC-Labeled Human CD19 (20-291) Protein, His Tag Star Staining | Order |
| Mesothelin | MSN-HF2H3 | FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag Star Staining | Order |
| Siglec-2 | SI2-HF2H4 | FITC-Labeled Human Siglec-2 / CD22 Protein, His Tag Star Staining | Preorder |
| FMC63 | FM3-FY57P1 | FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) Star Staining | Preorder |
| CD19 | CD9-HP2H5 | PE-Labeled Human CD19 (20-291) Protein, His Tag Star Staining | Preorder |
| BCMA | BCA-HP2H7 | PE-Labeled Human BCMA / TNFRSF17 Protein, His Tag Star Staining | Preorder |
| Mesothelin | MSN-HP2H8 | PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag Star Staining | Preorder |
| CD19 | CD9-HA2H9 | APC-Labeled Human CD19 (20-291) Protein, His Tag Star Staining | Preorder |
| BCMA | BCA-HA2H4 | APC-Labeled Human BCMA / TNFRSF17 Protein, His Tag Star Staining | Preorder |
| Mesothelin | MSN-HA2H6 | APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag Star Staining | Preorder |
| Cat. No. | Species | Product Description | Application | Preorder/Order |
|---|
| FM3-Y45 | Mouse | Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed | CAR expression by flow cytometry in preclinical and clinical samples | Order |
| FM3-FY45 | Mouse | FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed | Order |
| FM3-BY45 | Mouse | Biotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed | Order |
| FM3-Y45P1 | Mouse | Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293) DMF Filed | Order |
| FM3-HPY53 | Mouse | PE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) DMF Filed | Order |
| FM3-BY54 | Mouse | Biotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1, Avitag™ (Y45) DMF Filed | Order |
| FM3-FY45P1 | Mouse | FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293) | Order |
| FM3-Y45A1 | Mouse | Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Carrier-free) (recommended for ADA assay) DMF Filed | ADA assay development | Order |
| FM3-S93 | Rabbit | Rabbit Anti-Mouse FMC63 scFv Polyclonal Antibody (recommended for ADA assay) (MALS verified) | Order |
| Cat. No. | Product Description | Application | Preorder/Order |
|---|
| MBS-C001 | Anti-CD3/CD28 Antibody-coupled Magnetic Beads | Cell activation and expansion | Order |
| Molecule | Cat. No. | Product Description | Preorder/Order |
|---|
| IFN-γ | CRS-A001 | Human Interferon-γ(IFN-γ) ELISA Kit | Preorder |
| TNF-α | CRS-A002 | Human Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit coming soon | Inquiry |
| IL-2 | CRS-A003 | Human Interleukin-2(IL-2) ELISA Kit coming soon | Inquiry |
| IL-4 | CRS-A004 | Human Interleukin-4(IL-4) ELISA Kit coming soon | Inquiry |
| IL-6 | CRS-A005 | Human Interleukin-6(IL-6) ELISA Kit coming soon | Inquiry |
| IL-7 | CRS-A006 | Human Interleukin-7(IL-7) ELISA Kit coming soon | Inquiry |
| IL-8 | CRS-A007 | Human Interleukin-8(IL-8) ELISA Kit coming soon | Inquiry |
| IL-10 | CRS-A008 | Human Interleukin-10(IL-10) ELISA Kit coming soon | Inquiry |
| IL-15 | CRS-A009 | Human Interleukin-15(IL-15) ELISA Kit coming soon | Inquiry |
| IL-21 | CRS-A010 | Human Interleukin-21(IL-21) ELISA Kit coming soon | Inquiry |
| IL-12p70 | CRS-A011 | Human Interleukin-12p70(IL-12p70) ELISA Kit coming soon | Inquiry |
| IL-1beta | CRS-A012 | Human Interleukin-1beta(IL-1beta) ELISA Kit coming soon | Inquiry |
| GM-CSF | CRS-A013 | Human Macrophage Colony Stimulating Factor 2(GM-CSF) ELISA Kit coming soon | Inquiry |
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