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Your Position: Home > Cell > HVEM > SCRAJ-STF108

Raji/Human HVEM Stable Cell Line Development Service

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  • Description
    The Raji/Human HVEM Stable Cell Line was engineered to express full length human HVEM (Gene ID: 8764), used to mimic cancer target cells. Surface expression of human HVEM was confirmed by flow cytometry.
  • Application

    • Useful for cell-based HVEM binding assay

    • Useful as HVEM-expressing target cells in reporter gene assay

  • Growth Properties
    Suspension
  • Selection Marker
    NA
  • Culture Medium
    1640 medium + 10% FBS
  • Freeze Medium
    Serum-free cell cryopreservation medium
  • Quantity
    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium
  • Storage
    Frozen in liquid nitrogen.
  • Mycoplasma Testing
    Negative
  • Sterility Testing
    Negative
  • Instructions for Use
    See data sheet for detailed culturing and assay protocol.
Receptor Assay
 HVEM FACS

Expression analysis of human HVEM on Raji/Human HVEM Stable Cell Line by FACS.
Raji/Human HVEM Stable Cell Line or negative control cell were stained with PE-labeled anti-Human HVEM antibody.

Passage Stability
 HVEM PASSAGE

Passage stability analysis of receptor expression by FACS.
Flow cytometry surface staining of human HVEM on Raji/Human HVEM Stable Cell Line demonstrates consistent mean fluorescent intensity across passage 10-22.

Please contact us if you are interested in related cell pool service.

  • Background
    Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
  • Permits & Restrictions
    This cell line is provided for research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. You are not allowed to share, distribute, sell, modify, sublicense, or otherwise make this cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. AcroBiosystems does not warrant the suitability of this cell line for any particular use, and does not accept any liability in connection with the handling or use of this cell line.
  • Clinical and Translational Updates

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ETA of in-stock products: 2 business days

Price(USD) : $3500.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Preclinical

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