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Your Position: Home > Protein > Integrin alpha 11 beta 1 > IT1-C52W9

Canine Integrin alpha 11 beta 1 (ITGA11&ITGB1) Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha 11 beta 1,ITGA11&ITGB1
  • Source
    Canine ITGA11&ITGB1 Heterodimer Protein, His Tag&Tag Free(IT1-C52W9) is expressed from human 293 cells (HEK293). It contains AA Asp 21 - Pro 1142 (ITGA11) & Asp 23 - Asp 728 (ITGB1) (Accession # A0A8I3S131-1 (ITGA11) & A0A8C0PYR6-1 (ITGB1)).
    Predicted N-terminus: Asp 21 (ITGA11) & Asp 23 (ITGB1)
  • Molecular Characterization
    Integrin alpha 11 beta 1 Structure

    Canine ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA1 and ITGB1, has a calculated MW of 132.6 kDa (ITGA11) and 83.2 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris,150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Integrin alpha 11 beta 1 SDS-PAGE

Canine ITGA11&ITGB1 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
 Integrin alpha 11 beta 1 ELISA

Immobilized Native Human Collagen I protein at 10 μg/mL (100 μL/well) can bind Canine ITGA11&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-C52W9) with a linear range of 0.078-5 μg/mL (QC tested).

 Integrin alpha 11 beta 1 ELISA

Immobilized Native Human Collagen IV Protein at 10 μg/mL (100 μL/well) can bind Canine ITGA11&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-C52W9) with a linear range of 0.01-0.313 μg/mL (Routinely tested).

  • Background
    Integrin alpha 11 beta 1 is a receptor for collagen. The alpha11 cDNA encodes a mature protein with a large 1120-residue extracellular domain that contains an I-domain of 207 residues and is linked by a transmembrane domain to a short cytoplasmic domain of 24 amino acids. The deduced alpha11 protein shows the typical structural features of integrin alpha-subunits and is similar to a distinct group of alpha-subunits from collagen-binding integrins.
  • Clinical and Translational Updates

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