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Your Position: Home > Protein > IFN-alpha/beta R1 > IF1-H5225

Human IFN-alpha / beta R1 Protein, His Tag (MALS verified)

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  • Synonym
    IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1
  • Source
    Human IFN-alpha / beta R1 Protein, His Tag(IF1-H5225) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # P17181-1).
    Predicted N-terminus: Lys 28
  • Molecular Characterization
    IFN-alpha/beta R1 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 49.0 kDa. The protein migrates as 65-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IFN-alpha/beta R1 SDS-PAGE

Human IFN-alpha / beta R1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
IFN-alpha/beta R1 MALS images

The purity of Human IFN-alpha / beta R1 Protein, His Tag (Cat. No. IF1-H5225) is more than 85% and the molecular weight of this protein is around 67-81 kDa verified by SEC-MALS.

Bioactivity-BLI
 IFN-alpha/beta R1 BLI

Loaded Human IFNAR1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 2b Protein, Fc Tag (Cat. No. IFB-H5253) with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

 IFN-alpha/beta R1 BLI

Loaded Human IFN-alpha / beta R1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) with an affinity constant of 11.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

  • Background
    Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
  • Clinical and Translational Updates

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