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Your Position: Home > IL-17C

IL-17C

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Cat. No. Species Product Description Structure Purity Feature
ILC-M52H7 Mouse Mouse IL-17C Protein, His Tag
ILC-M52H7-structure
ILC-M52H7-sds
ILC-M82E9 Mouse Biotinylated Mouse IL-17C Protein, His,Avitag™ (MALS verified)
ILC-M82E9-structure
ILC-M82E9-sds
ILC-H52H7 Human Human IL-17C Protein, His Tag
ILC-H52H7-structure
ILC-H52H7-sds
ILC-H82E5 Human Biotinylated Human IL-17C Protein, His,Avitag™ (MALS verified)
ILC-H82E5-structure
ILC-H82E5-sds
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Part of Bioactivity data

ILC-H52H7-BLI
IL-17C BLI

Loaded Human IL-17 RE (155-454), Fc Tag (Cat. No. ILE-H5256) on Protein A Biosensor, can bind Human IL-17C, His Tag (Cat. No. ILC-H52H7) with an affinity constant of 0.714 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
ILC-M82E9-ELISA
IL-17C ELISA

Immobilized Human IL-17 RE (155-454), Fc Tag (Cat. No. ILE-H5256) at 2 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-17C, His,Avitag (Cat. No. ILC-M82E9) with a linear range of 0.2-20 ng/mL (QC tested).

Protocol

Synonym Name

IL-17C,Cytokine CX2,IL17C

Background

Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL‑17C binds to IL‑17 RE with high affinity and to IL‑17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.

Clinical and Translational Updates

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