Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-23R

IL-23R

Brief Information

Name:Interleukin 23 Receptor
Target Synonym:IL-23 receptor,IL23R,Interleukin 23 Receptor,Interleukin-23 Receptor,IL-23R
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:NDA/BLA

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ILR-C5251 Cynomolgus Cynomolgus IL-23 R Protein, Fc Tag
ILR-C5251-structure
ILR-C5251-sds
ILR-H82F3 Human Biotinylated Human IL-23 R Protein, Fc,Avitag™ (MALS verified)
ILR-H82F3-structure
ILR-H82F3-sds
ILR-H5254 Human Human IL-23 R Protein, Fc Tag (MALS verified)
ILR-H5254-structure
ILR-H5254-sds
ILR-H52H4 Human Human IL-23 R Protein, His Tag (MALS & SPR verified)
ILR-H52H4-structure
ILR-H52H4-sds
ILR-M5251 Mouse Mouse IL-23 R Protein, Fc Tag
ILR-M5251-structure
ILR-M5251-sds
ACRO Quality

Part of Bioactivity data

ILR-H5254-SPR
IL-23R SPR

Captured Human IL-23 R, Fc Tag (Cat. No. ILR-H5254) on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL23A & IL12B, His Tag (Cat. No. ILB-H52W5)with an affinity constant of 5.36 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
ILR-H52H4-SPR
IL-23R SPR

Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-H82W6) captured on Biotin CAP - Series S sensor Chip can bind Human IL-23 R, His Tag (SPR verified) (Cat. No. ILR-H52H4) with an affinity constant of 3.39 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

IL-23 R,IL-23 Receptor

Background

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PN-235 JNJ-77242113; PN-235; JNJ-2113; PN-21235; JNJ-77242113-AAC Phase 3 Clinical Protagonist Therapeutics Inc Psoriasis; Colitis, Ulcerative; Plaque psoriasis Details
PN-232 PN-232; JNJ75105186 Phase 1 Clinical Protagonist Therapeutics Inc Details
PN-235 JNJ-77242113; PN-235; JNJ-2113; PN-21235; JNJ-77242113-AAC Phase 3 Clinical Protagonist Therapeutics Inc Psoriasis; Colitis, Ulcerative; Plaque psoriasis Details
PN-232 PN-232; JNJ75105186 Phase 1 Clinical Protagonist Therapeutics Inc Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap