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Your Position: Home > CD27

CD27

Brief Information

Name:CD27 antigen
Target Synonym:CD27 antigen,Tumor necrosis factor receptor superfamily member 7,CD27L receptor,CD27,CD27 Molecule,T-Cell Activation Antigen CD27,TNFRSF7,T14,T Cell Activation Antigen S152,S152. LPFS2,S152,Tp55,Tumor Necrosis Factor Receptor Superfamily, Member 7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD7-R52H9 Rat Rat CD27 / TNFRSF7 Protein, His Tag
CD7-R52H9-structure
CD7-R52H9-sds
CD7-H522b Human Human CD27 / TNFRSF7 Protein, His Tag (MALS verified)
CD7-H522b-structure
CD7-H522b-sds
CD7-M5252 Mouse Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M5252-structure
CD7-M5252-sds
CD7-H5257 Human Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257-structure
CD7-H5257-sds
CD7-C5259 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-C5259-structure
CD7-C5259-sds
TN7-H82F6 Human Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
TN7-H82F6-structure
TN7-H82F6-sds
CD7-H5254 Human Human CD27 / TNFRSF7 Protein, Fc Tag (HPLC verified)
CD7-H5254-structure
CD7-H5254-sds
CD7-H5254-hplc
ACRO Quality

Part of Bioactivity data

CD7-H5257-Cell-based assay
CD27 FACS

Flow Cytometry assay shows that Human CD27 Protein, Mouse IgG2a Fc Tag (Cat. No. CD7-H5257) can bind to Raji cells Surface Human CD70. The concentration of CD27 used is 10 μg/mL (Routinely tested).

Protocol
TN7-H82F6-Cell-based assay
CD27 FACS

Flow Cytometry assay shows that Biotinylated Human CD27, Fc,Avitag (Cat. No. TN7-H82F6) can bind to Raji cells Surface Human CD70. The concentration of CD27 used is 10 μg/mL (Routinely tested).

Protocol
CD7-H522b-ELISA
CD27 ELISA

Immobilized Human CD27, His Tag (Cat. No. CD7-H522b) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD27 Ligand Protein, Avitag,Fc Tag with a linear range of 1-31 ng/mL (QC tested).

Protocol
CD7-H522b-MALS-HPLC
CD27 MALS images

The purity of Human CD27, His Tag (Cat. No. CD7-H522b) is more than 85% and the molecular weight of this protein is around 32-47 kDa verified by SEC-MALS.

Synonym Name

CD27,TNFRSF7,S152,T14,Tp55

Background

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

Clinical and Translational Updates

Related Molecule

CD27 ligand

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Boserolimab MK-5890 Phase 2 Clinical Merck & Co Inc Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Varlilumab CDX-1127 Phase 2 Clinical Celldex Therapeutics Gallbladder Neoplasms; Lymphoma, Primary Effusion; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Bile Duct Neoplasms; Urologic Neoplasms; Astrocytoma; Lymphoma, T-Cell; Burkitt Lymphoma; Lymphoma, Non-Hodgkin; Plasmablastic Lymphoma; Lung Neoplasms; Urogenital Neoplasms; Lymphoma; Glioma; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Biliary Tract Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Lymphomatoid Granulomatosis; Skin Neoplasms; Lymphoma, B-Cell; Kidney Diseases; Neoplasms; Glioblastoma; Triple Negative Breast Neoplasms; Urologic Diseases; Urinary Bladder Neoplasms; Oligodendroglioma; Prostatic Neoplasms Details
GEN-1053 BNT-313; GEN-1053 Phase 2 Clinical Genmab A/S Solid tumours Details
LOR-S03 CDX-527 Phase 1 Clinical Celldex Therapeutics Ovarian Neoplasms; Solid tumours; Liver Neoplasms; Head and Neck Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Neoplasms; Microsatellite instability-high cancer; Urinary Bladder Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 Phase 1 Clinical Aduro Biotech Inc Neoplasms Details
Boserolimab MK-5890 Phase 2 Clinical Merck & Co Inc Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Varlilumab CDX-1127 Phase 2 Clinical Celldex Therapeutics Gallbladder Neoplasms; Lymphoma, Primary Effusion; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Bile Duct Neoplasms; Urologic Neoplasms; Astrocytoma; Lymphoma, T-Cell; Burkitt Lymphoma; Lymphoma, Non-Hodgkin; Plasmablastic Lymphoma; Lung Neoplasms; Urogenital Neoplasms; Lymphoma; Glioma; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Biliary Tract Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Lymphomatoid Granulomatosis; Skin Neoplasms; Lymphoma, B-Cell; Kidney Diseases; Neoplasms; Glioblastoma; Triple Negative Breast Neoplasms; Urologic Diseases; Urinary Bladder Neoplasms; Oligodendroglioma; Prostatic Neoplasms Details
GEN-1053 BNT-313; GEN-1053 Phase 2 Clinical Genmab A/S Solid tumours Details
LOR-S03 CDX-527 Phase 1 Clinical Celldex Therapeutics Ovarian Neoplasms; Solid tumours; Liver Neoplasms; Head and Neck Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Neoplasms; Microsatellite instability-high cancer; Urinary Bladder Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 Phase 1 Clinical Aduro Biotech Inc Neoplasms Details

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