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2B4

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Part of Bioactivity data

2B4-H82F0-ELISA
Biotinylated Human 2B4, Fc,AvitagBiotinylated Human 2B4, Fc,Avitag (Cat. No. 2B4-H82F0) ELISA bioactivity

Immobilized Human CD48, Fc tag at 10 μg/mL (100 μL/well) can bind Biotinylated Human 2B4, Fc,Avitag (Cat. No. 2B4-H82F0) with a linear range of 0.01-0.156 μg/mL (QC tested).

2B4-H82E9-ELISA
Biotinylated Human 2B4, Avitag,His Tag (recommended for biopanning)Biotinylated Human 2B4, Avitag,His Tag (recommended for biopanning) (Cat. No. 2B4-H82E9) ELISA bioactivity

Immobilized Biotinylated Human 2B4, Avitag,His Tag (recommended for biopanning) (Cat. No. 2B4-H82E9) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.2 μg/well) plate, can bind Human CD48, Fc Tag (Cat. No. BC1-H5255) with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

CD244,2B4,SLAMF4,NKR2B4,NAIL,h2B4

Background

Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

Clinical and Translational Updates

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