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VCAM-1

Brief Information

Name:Vascular cell adhesion molecule 1
Target Synonym:VCAM1,Vascular cell adhesion protein 1,V-CAM 1,CD106,Vascular Cell Adhesion Molecule 1,CD106 Antigen,INCAM-100,VCAM-1,Vascular Cell Adhesion Molecule-1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
VC1-H5253 Human Human VCAM-1 / CD106 Protein, Fc Tag (MALS verified)
VC1-H5253-structure
VC1-H5253-sds
VC1-H5253-elisa_1
VC1-H5224 Human Human VCAM-1 / CD106 Protein, His Tag
VC1-H5224-structure
VC1-H5224-sds
VC1-H5224-elisa_1

Part of Bioactivity data

VC1-H5224-ELISA
Human VCAM-1, His TagHuman VCAM-1, His Tag (Cat. No. VC1-H5224) ELISA bioactivity

Immobilized Human VCAM-1, His Tag (Cat. No. VC1-H5224) at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGA4&ITGB1 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT1-H82W1) with a linear range of 0.01-0.156 μg/mL (QC tested).

VC1-H5253-MALS-HPLC
Human VCAM-1, Fc Tag (Cat. No. ) MALS images

The purity of Human VCAM-1, Fc Tag (Cat. No. VC1-H5253) was more than 85% and the molecular weight of this protein is around 235-265 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human VCAM-1, Fc TagHuman VCAM-1, Fc Tag (Cat. No. VC1-H5253) ELISA bioactivity

Immobilized Human VCAM-1, Fc Tag (Cat. No. VC1-H5253) at 5 μg/mL (100 μL/well) can bind Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W1) with a linear range of 5-156 ng/mL (QC tested).

Synonym Name

VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1

Background

Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tocopherol acetate DSE-9912 Approved Ephynal, Aquasol E Venous Thromboembolism; Atherosclerosis; Intermittent Claudication; Thrombosis; Diabetic Retinopathy Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
99mTccAbVCAM1‐5 99mTccAbVCAM1‐5 Phase 1 Clinical Medico-Economic Evaluation Unit , University Hospital, Grenoble Atherosclerosis Details

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