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Your Position: Home > Nectin-1

Nectin-1

Brief Information

Name:Pregnane X receptor
Target Synonym:SXR,Nuclear Receptor Subfamily 1, Group I, Member 2,Pregnane X Nuclear Receptor Variant 2,ONR1,PAR1,PAR2,PARq,BXR,PAR,PRR,SAR,Pregnane X Receptor,PXR,NR1I2,Nuclear Receptor Subfamily 1 Group I Member 2,Orphan Nuclear Receptor PXR,Steroid And Xenobiotic Receptor,Orphan Nuclear Receptor PAR1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
PV1-H5253 Human Human Nectin-1 / PVRL1 / CD111 Protein, Fc Tag
PV1-H5253-structure
PV1-H5253-sds
PV1-H5223 Human Human Nectin-1 / PVRL1 / CD111 Protein, His Tag
PV1-H5223-structure
PV1-H5223-sds
ACRO Quality

Part of Bioactivity data

PV1-H5253-BLI
Nectin-1 BLI

Loaded Human Nectin-1, Fc Tag (Cat. No. PV1-H5253) on Protein A Biosensor, can bind Human Nectin-4, His Tag (Cat. No. NE4-H52H3) with an affinity constant of 0.271 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
PV1-H5253-BLI
Nectin-1 BLI

Loaded Cynomolgus Nectin-4, His Tag (Cat. No. NE4-C52H4) on HIS1K Biosensor, can bind Human Nectin-1, Fc Tag (Cat. No. PV1-H5253) with an affinity constant of 0.23 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

PVRL1,Nectin-1,CD111,CLPED1,ED4,HIgR,HVEC,OFC7,PRR,PRR1,PVRR,PVRR1,SK-12

Background

Poliovirus receptor-related protein 1 (PVRL1) is also known as Herpes virus entry mediator C (HveC), Herpesvirus Ig-like receptor (HIgR), Nectin-1, CD antigen CD111, PVRL1 / Nectin-1 / CD111 belongs to the nectin family. PVRL1 / Nectin-1 is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM). PVRL1 is adhesion molecule found in a wide range of tissues. PVRL1 / Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Crotamiton/Diphenhydramine Hydrochloride/Vitamin E/Glycyrrhetinic Acid Approved 安夫康 Dermatitis Details
Crotamiton/Diphenhydramine Hydrochloride/Vitamin E/Glycyrrhetinic Acid Approved 安夫康 Dermatitis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Vitamin E/Ascorbic Acid Phase 3 Clinical Advanced Medical Projects Fragile X Syndrome; Neuralgia Details
Lidocaine/Allantoin/Glycyrrhetinic Acid/Vitamin E Phase 2 Clinical Hemorrhoids; Warts; Pain; Fissure in Ano Details
Vitamin E/Ascorbic Acid Phase 3 Clinical Advanced Medical Projects Fragile X Syndrome; Neuralgia Details
Lidocaine/Allantoin/Glycyrrhetinic Acid/Vitamin E Phase 2 Clinical Hemorrhoids; Warts; Pain; Fissure in Ano Details

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