0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Mesothelin

Mesothelin

Brief Information

Name:Mesothelin
Target Synonym:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
MSN-H82E7 Human Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-H82E7-structure
MSN-H82E7-sds
MSN-H82E7-elisa_1
MSN-R52H4 Rat Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-R52H4-structure
MSN-R52H4-sds
MSN-R52H4-elisa_1
MBS-K024 Human Human Mesothelin-coupled Magnetic Beads
MBS-K024-elisa_1
MSN-M82E7 Mouse Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MSN-M82E7-structure
MSN-M82E7-sds
MSN-M82E7-elisa_1
MSN-HP2H5 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-C52H6 Cynomolgus Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-C52H6-structure
MSN-C52H6-sds
MSN-C52H6-elisa_1
MSN-M52H3 Mouse Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-M52H3-structure
MSN-M52H3-sds
MSN-M52H3-elisa_1
MSN-HF25x Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF25x-structure
MSN-HF25x-sds
MSN-HF25x-elisa_1
MSN-HR2P4 Human RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4-structure
MSN-HR2P4-sds
MSN-HR2P4-elisa_1
MSN-HR2P4-elisa_2
MSN-HG2P4 Human GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4-structure
MSN-HG2P4-sds
MSN-HG2P4-elisa_1
MSN-HG2P4-elisa_2
MSN-HP223 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HP223-structure
MSN-HF223 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF223-structure
MSN-HF223-sds
MSN-HF223-elisa_1
MSN-HF253 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF253-structure
MSN-HF253-sds
MSN-HF253-elisa_1
MSN-H82F6 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™
MSN-H82F6-structure
MSN-H82F6-sds
MSN-H82F6-elisa_1
MSN-H522a Human Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin
MSN-H522a-structure
MSN-H522a-sds
MSN-H522a-elisa_1
MSN-H5253 Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H5253-structure
MSN-H5253-sds
MSN-H5253-hplc
MSN-H5253-elisa_1
MSN-H82E9 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified)
MSN-H82E9-structure
MSN-H82E9-sds
MSN-H82E9-elisa_1
MSN-H826x Human Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H826x-structure
MSN-H826x-sds
MSN-H826x-elisa_1
MSN-H8223 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H8223-structure
MSN-H8223-sds
MSN-H8223-elisa_1
MSN-H526x Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H526x-structure
MSN-H526x-sds
MSN-H526x-elisa_1
MSN-H5223 Human Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-H5223-structure
MSN-H5223-sds
MSN-H5223-elisa_1
MSN-H5223-elisa_2
MSN-H5222 Human Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5222-structure
MSN-H5222-sds

Part of Bioactivity data

MSN-HF223-Cell-based assay
Evaluation of CAR expression

293 cells were transfected with anti-MSLN-scFv and RFP tag. 2e5 of the cells were stained with B. FITC-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HF223, 1 μg/mL) and C. FITC-labeled protein control. A. Non-transfected 293 cells and C. FITC-labeled protein control were used as negative control. RFP was used to evaluate CAR (anti-MSLN-scFv) expression and FITC was used to evaluate the binding activity of FITC-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HF223).

MSN-HR2P4-SPR
Human_FcRn_Heterodimer_Protein_SPR

can bind Human MS4A1 / CD20 Full Length Protein, His Tag (Cat. No. CD0-H55Ha)with an affinity constant of 1.21 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

MSN-HG2P4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-human MSLN MAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind GFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HG2P4) with an affinity constant of 0.542 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

MSLN,Mesothelin,MPF

Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
iCasp9M28z iCasp9M28z Phase 1 Clinical Memorial Sloan Kettering Cancer Center Mesothelioma; Breast Neoplasms; Lung Neoplasms; Neoplasm Metastasis Details
LMB-100 LMB-100; RG-7787; RO-6927005 Phase 2 Clinical F. Hoffmann-La Roche Ltd Neoplasms; Mesothelioma Details
ATA-2271 ATA-2271 Phase 1 Clinical Memorial Sloan Kettering Cancer Center, Atara Biotherapeutics Mesothelioma Details
MCY-M11 MCY-M11 Phase 1 Clinical Maxcyte Ovarian Neoplasms; Mesothelioma; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Adenocarcinoma Details
BMS-986148 BMS-986148 Phase 2 Clinical Bristol-Myers Squibb Company Neoplasms Details
RNA-Meso-CIR-T RNA-Meso-CIR-T Phase 1 Clinical Novartis Pharma Ag, University Of Pennsylvania Mesothelioma Details
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 Phase 2 Clinical Bayer Ag, Morphosys Ovarian Neoplasms; Neoplasms; Mesothelioma; Carcinoma, Non-Small-Cell Lung Details
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) Phase 2 Clinical Shanghai Cell Therapy Research Institute Neoplasms Details
KD-021 (Nanjing KAEDI Biotech) KD-021 Phase 1 Clinical Nanjing Kaedi Biotechnology Co Ltd Neoplasms Details
Anti-mesothelin CAR-T (Pregene) Clinical Pregene (Shenzhen) Biotechnology Co Ltd Hydrothorax Details
Anti-mesothelin CAR-T (Legend) Phase 1 Clinical Ovarian Neoplasms Details
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) Details
anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 Phase 1 Clinical Bayer Ag Ovarian Neoplasms; Mesothelioma Details
Amatuximab MORAb-009; MORAB-009-006 Phase 2 Clinical National Cancer Institute Ovarian Neoplasms; Neoplasms; Pancreatic Neoplasms; Mesothelioma; Carcinoma, Non-Small-Cell Lung Details
ABBV-428 ABBV-428; ABBV428 Phase 1 Clinical Abbvie Inc Solid tumours Details
Anti-MESO CAR-T cell(Ruijin Hospital) Phase 1 Clinical Ruijin Hospital, Shanghai Jiaotong University School Of Medicine Neoplasms Details

This web search service is supported by Google Inc.

totop