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Your Position: Home > IL-1RL1

IL-1RL1

Brief Information

Name:Interleukin-1 receptor-like 1
Target Synonym:ST2,IL1RL1,Protein ST2,DER4,T1,Interleukin 1 Receptor Like 1,Homolog Of Mouse Growth Stimulation-Expressed,Interleukin 1 Receptor-Related Protein,Growth Stimulation-Expressed,FIT-1,IL33R,ST2L,ST2V,Interleukin-1 Receptor-Like 1 Protein,EC:3.2.2.6,Interleukin-1 Receptor-Like 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:NDA/BLA

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Cat. No. Species Product Description Structure Purity Feature
IL1-H82F8 Human Biotinylated Human IL-1RL1 / ST2 Protein, Fc,Avitag™ (MALS verified)
IL1-H82F8-structure
IL1-H82F8-sds
IL1-M5259 Mouse Mouse IL-1RL1 / ST2 Protein, Fc Tag
IL1-M5259-structure
IL1-M5259-sds
IL1-H82E9 Human Biotinylated Human IL-1RL1 / ST2 Protein, His,Avitag™ (MALS verified)
IL1-H82E9-structure
IL1-H82E9-sds
IL1-H5250 Human Human IL-1RL1 / ST2 Protein, Fc Tag
IL1-H5250-structure
IL1-H5250-sds
IL1-H5229 Human Human IL-1RL1 / ST2 Protein, His Tag (MALS verified)
IL1-H5229-structure
IL1-H5229-sds
ACRO Quality

Part of Bioactivity data

IL1-H5250-BLI
IL-1RL1 BLI

Loaded Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) on Protein A Biosensor, can bind with Biotinylated Human IL-33, His,Avitag (Cat. No. IL3-H82H5) an affinity constant of 1.81 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
IL1-H82E9-ELISA
IL-1RL1 ELISA

Immobilized Human IL-33 Protein, His Tag (Cat. No. IL3-H52H7) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-1RL1, His,Avitag (Cat. No. IL1-H82E9) with a linear range of 0.3-10 ng/mL (QC tested).

Protocol

Synonym Name

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

Background

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

Clinical and Translational Updates

Related Molecule

IL-33

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Astegolimab AMG-282; RG-6149; RO-7187807 Phase 3 Clinical Amgen Inc, F. Hoffmann-La Roche Ltd Coronavirus Disease 2019 (COVID-19); Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Recombinant humanized anti-ST2 monoclonal antibody 9-MW1911; 9MW-1911; 9-MW-1911; 9MW1911 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Melrilimab GSK-3772847; CNTO-7160 Phase 2 Clinical Johnson & Johnson Innovative Medicine Asthma Details
TQC-2938 TQC2938; TQC-2938 Phase 1 Clinical Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group Asthma Details
Astegolimab AMG-282; RG-6149; RO-7187807 Phase 3 Clinical Amgen Inc, F. Hoffmann-La Roche Ltd Coronavirus Disease 2019 (COVID-19); Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Recombinant humanized anti-ST2 monoclonal antibody 9-MW1911; 9MW-1911; 9-MW-1911; 9MW1911 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Melrilimab GSK-3772847; CNTO-7160 Phase 2 Clinical Johnson & Johnson Innovative Medicine Asthma Details
TQC-2938 TQC2938; TQC-2938 Phase 1 Clinical Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group Asthma Details

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