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Your Position: Home > IL-18BP

IL-18BP

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Cat. No. Species Product Description Structure Purity Feature
ILP-H82E3 Human Biotinylated Human IL-18BP Protein, His,Avitag™ (SPR verified)
ILP-H82E3-structure
ILP-H82E3-sds
ILP-H5253 Human Human IL-18BP Protein, Fc Tag (MALS verified)
ILP-H5253-structure
ILP-H5253-sds
ILP-H5222 Human Human IL-18BP Protein, His Tag (MALS & SPR verified)
ILP-H5222-structure
ILP-H5222-sds
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Part of Bioactivity data

ILP-H5222-Cell-based assay
IL-18BP CELL

Human IL-18BP, His Tag (Cat. No. ILP-H5222) inhibits the IL-18-induced IFN-gamma secretion by KG‑1 cells. The ED50 for this effect is 0.019-0.053 µg/mL in the presence of 30 ng/mL of Recombinant Human IL‑18 (Routinely tested).

Protocol
ILP-H82E3-SPR
IL-18BP SPR

Human IL-18 Protein, premium grade (Cat. No. IL8-H5114) immobilized on CM5 Chip can bind Biotinylated Human IL-18BP Protein, His,Avitag (Cat. No. ILP-H82E3) with an affinity constant of 0.184 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
ILP-H5253-SPR
IL-18BP SPR

Human IL-18BP, Fc Tag (Cat. No. ILP-H5253) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-18, Tag Free with an affinity constant of 1.71 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

IL18BP,IL18BPa,Tadekinig-alfa

Background

Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

Clinical and Translational Updates

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