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NCAM-1

Brief Information

Name:Neural cell adhesion molecule 1
Target Synonym:Neural cell adhesion molecule 1,CD56,NCAM1,NCAM,Neural Cell Adhesion Molecule, NCAM,CD56 Antigen,N-CAM-1,MSK39,NCAM-1,Antigen Recognized By Monoclonal Antibody 5.1H11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

NC1-H82E3-ELISA
Biotinylated Human NCAM-1, His,AvitagBiotinylated Human NCAM-1, His,Avitag (Cat. No. NC1-H82E3) ELISA bioactivity

Immobilized Biotinylated Human NCAM-1, His,Avitag (Cat. No. NC1-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NCAM-1 Antibody, Human IgG1 with a linear range of 1-5 ng/mL (QC tested).

NC1-H82E3-MALS-HPLC
Biotinylated Human NCAM-1, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human NCAM-1, His,Avitag (Cat. No. NC1-H82E3) was more than 90% and the molecular weight of this protein is around 115-125 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human NCAM-1, His,AvitagBiotinylated Human NCAM-1, His,Avitag (Cat. No. NC1-H82E3) ELISA bioactivity

Immobilized Biotinylated Human NCAM-1, His,Avitag (Cat. No. NC1-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NCAM-1 Antibody, Human IgG1 with a linear range of 1-5 ng/mL (QC tested).

Synonym Name

CD56,MSK39,NCAM1,N-CAM-1

Background

NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lorvotuzumab mertansine BB-10901; IMGN-901; huN-901-DM1; IMGN-901-TAP; huN-901-SPP-DM1 Phase 2 Clinical Immunogen Inc Ovarian Neoplasms; Hematologic Neoplasms; Carcinoma, Merkel Cell; Small Cell Lung Carcinoma; Multiple Myeloma; Carcinoma, Small Cell Details

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