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Cat. No. Species Product Description Structure Purity Feature
NKC-C5247 Cynomolgus Cynomolgus NKG2C / CD159c Protein, His Tag
NKC-H5248 Human Human NKG2C / CD159c Protein, His Tag

Synonym Name

NKG2C,NKG2-C,CD159c,KLRC2,NK cell receptor C


Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. NKG2C plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E is coupled to the KARAP/DAP12 adapter in a subset of NK cells, triggering their effector functions. CD94/NKG2C may operate as an alternative activation pathway for a subset of CD8+ T lymphocytes, triggering their effector functions and proliferation upon specific ligand engagement.

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