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Your Position: Home > CD206

CD206

Brief Information

Name:Macrophage mannose receptor 1
Target Synonym:C-type lectin domain family 13 member D,Macrophage mannose receptor 1-like protein 1,hMR,Macrophage mannose receptor 1,C-type lectin domain family 13 member D-like,CLEC13DL,MRC1L1,MRC1,Mannose Receptor C-Type 1,Mannose Receptor, C Type 1-Like 1,Human Mannose Receptor,MMR,Mannose Receptor, C Type 1,CD206 Antigen,BA541I19.1,CD206,CLEC13D,Macrophage Mannose Receptor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CD6-M82E8 Mouse Biotinylated Mouse CD206 / MMR Protein, His,Avitag™
CD6-M82E8-structure
CD6-M82E8-sds
CD6-M52H7 Mouse Mouse CD206 / MMR Protein, His Tag
CD6-M52H7-structure
CD6-M52H7-sds
CD6-H82H6 Human Biotinylated Human CD206 / MMR Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)
CD6-H82H6-structure
CD6-H82H6-sds
CD6-H52H9 Human Human CD206 / MMR Protein, His Tag
CD6-H52H9-structure
CD6-H52H9-sds
ACRO Quality

Part of Bioactivity data

CD6-H82H6-SPR
CD206 MALS images

The purity of Biotinylated Human CD206 Protein, His Tag, primary amine labeling (Cat. No. CD6-H82H6) is more than 90% and the molecular weight of this protein is around 180-210 kDa verified by SEC-MALS.

Synonym Name

MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1

Background

CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Technetium Tc 99m tilmanocept NEO3-09 Approved University Of California Lymphoseek Kit, Lymphoseek, Lymphoaim United States Solid tumours; Head and Neck Neoplasms; Melanoma; Carcinoma, Squamous Cell; Breast Neoplasms; Diagnostic agents Cardinal Health 414 Llc 2013-03-13 Arthritis, Rheumatoid; Uterine Cervical Neoplasms; Sarcoma, Kaposi; Melanoma; Endometrial Neoplasms; Diagnostic agents; Carcinoma, Squamous Cell; Colorectal Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Liver Neoplasms; Colonic Neoplasms; Non-alcoholic Fatty Liver Disease; Anus Neoplasms; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Head and Neck Neoplasms; Solid tumours; HIV Infections Details

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