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Designed under ISO 9001:2015 and ISO 13485:2016
Manufactured and QC tested under a GMP compliance factory
FDA DMF filed
Animal-Free materials
Beta-lactam materials free
Batch-to-batch consistency
Stringent quality control tests
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 80.7 kDa. The protein migrates as 90 kDa±3 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.
Contact us for customized product form or formulation.
This product is supplied and shipped with blue ice, please inquire the shipping cost.
Upon receipt, store it immediately at -20°C or lower for long term storage.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
GMP Human DLL4 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28) captured on Protein A Chip can bind Human NOTCH1 Protein, His Tag, premium grade (Cat. No. NO1-H52H3) with an affinity constant between 1.00 nM - 150 nM as determined in a SPR assay (Biacore 8K) (QC tested).
CD34+ CD45+ hematopoietic cells were seeded on GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28) - coated plates and differentiated for 26 days, then flow cytometry was used to detect the expression of T-cell progenitor markers, CD7 and CD5. GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28) together with other growth factors could induce the formation of CD7+ and CD7+ CD5+ T-cell progenitors. However, the cells cultured without GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28) - coated plates expressed neither CD5 nor CD7.
The Recombinant Fibronectin fragment, premium grade (Cat. No. FIN-H5116) combined with GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28), GMP Human VCAM-1 Protein, Fc Tag (Cat. No. GMP-VC1H25) coating on the plate could efficiently induce hematopoietic stem cells differentiation to NK cells, with high expression of CD56+ CD3-.
The SPR based assay shows that GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28) is stable at 37℃ for 24 hours.
The SPR based assay shows that GMP Human DLL4 Protein, Fc Tag (Cat. No. GMP-DL4H28) is stable after freezing and thawing 3 times.
ACROBiosystems GMP grade products are produced under a quality management system and in compliance with relevant guidelines: Ph. Eur General Chapter 5.2.12 Raw materials of biological origin for the production of cell-based and gene therapy medicinal products; USP<92>Growth Factors and Cytokines Used in Cell Therapy Manufacturing; USP<1043>Ancillary Materials for Cell, Gene, and Tissue-Engineered Products; ISO/TS 20399-1:2018, Biotechnology - Ancillary Materials Present During the Production of Cellular Therapeutic Products.
ACROBiosystems Quality Management System Contents：
Designed under ISO 9001:2015 and ISO 13485:2016, Manufactured and QC tested under a GMP compliance factory.
Animal-Free materials
Materials purchased from the approved suppliers by QA
ISO 5 clean rooms and automatic filling equipment
Qualified personnel
Quality-related documents review and approve by QA
Fully batch production and control records
Equipment maintenance and calibration
Validation of analytical procedures
Stability studies conducted
Comprehensive regulatory support files
Request For Regulatory Support Files（RSF）
ACROBiosystems provide rigorous quality control tests (fully validated equipment, processes and test methods) on our GMP grade products to ensure that they meet stringent standards in terms of purity, safety, activity and inter-batch stability, and each bulk QC lot mainly contains the following specific information:
SDS-PAGE
Protein content
Endotoxin level
Residual Host Cell DNA content
Residual Host Cell Protein content
Biological activity analysis
Microbial testing
Mycoplasma testing
In vitro virus assay
Batch-to-batch consistency
To support your cell therapy development, you may add up to 3 GMP-grade cytokines (such as IL-2, IL-15, IL-7, and more) to your cart for FREE when you order GMP-grade DLL4.
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