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Your Position: Home > Protein > CD206 > CD6-C52H4

Cynomolgus CD206 / MMR Protein, His Tag

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  • Synonym
    MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1
  • Source
    Cynomolgus CD206 Protein, His Tag(CD6-C52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Glu 1332 (Accession # A0A7N9IAL7).
    Predicted N-terminus: Leu 20
  • Molecular Characterization
    CD206 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 152.3 kDa.

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.
  • Clinical and Translational Updates

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Price(USD) : $368.00

Price(USD) : $2426.00

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Drug Development Status

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Approved

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