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Human TROP-2 / TACSTD2 Protein, His Tag, low endotoxin (MALS verified)

COADS MS
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Cat. No. / Size
Price
Qty
TR2-H5223-200ug
$340.00
TR2-H5223-1mg (200ug X 5)
$1530.00
ETA of in-stock products:2 business days
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Product Details

  • Synonym

    TACSTD2, GA733-1, M1S1, TROP2

  • Source

    Human TROP-2, His Tag (TR2-H5223) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274 (Accession # P09758-1).

    Predicted N-terminus: Gln 31

    Request for sequence

  • Molecular Characterization

    TROP-2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 29.4 kDa. The protein migrates as 43-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 12 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TROP-2 SDS-PAGE

    Human TROP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TROP-2 SEC-MALS

    The purity of Human TROP-2, His Tag (Cat. No. TR2-H5223) is more than 95% and the molecular weight of this protein is around 33-50 kDa verified by SEC-MALS.

    Report

  • Bioactivity-ELISA

    TROP-2 ELISA

    Immobilized Human TROP-2, His Tag (Cat. No. TR2-H5223) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2, Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol

  • Bioactivity-SPR

    TROP-2 SPR

    Captured Trop2 antibody on CM5 chip via anti-mouse antibodies surface can bind Human TROP-2, His Tag (Cat. No. TR2-H5223) with an affinity constant of 5.98 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

    Protocol

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Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Recent Advances

 
Drug Development Progress
  • English Name：

    Tumor-associated calcium signal transducer 2

  • Category：

  • Approved Drugs：

    3 Details

  • Drugs in Clinical Trials：

    25 Details

  • Highest Development Stage：

    Approved

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