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Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (MALS verified)

COADS MS
DS

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Cat. No. / Size
Price
Qty
TAU-H5117-100ug
$305.00
TAU-H5117-1mg
$2045.00
ETA of in-stock products:2 business days
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Product Details

  • Synonym

    DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

  • Source

    Human Tau-441, Tag Free (TAU-H5117) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).

    Predicted N-terminus: Met 1

    Request for sequence

  • Molecular Characterization

    Tau Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 45.8 kDa. The protein migrates as 30-53 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Sterility

    Negative

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Tau SDS-PAGE

    Human Tau-441, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Tau SEC-MALS

    The purity of Human Tau-441, Tag Free (Cat. No. TAU-H5117) is more than 95% and the molecular weight of this protein is around 38-55 kDa verified by SEC-MALS.

    Report

  • Bioactivity-ThT Assay

    Tau THT

    Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when tau wild-type monomers (Cat. No. TAU-H5117) are combined with tau wild-type Pre-formed Fibrils (Cat. No. TAU-H5115) (Routinely tested).

    Protocol

  • Bioactivity-ELISA

    Tau ELISA

    Immobilized Human Tau-441, Tag Free (Cat. No. TAU-H5117) at 1 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.4-6 ng/mL (QC tested).

    Protocol

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Background

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Recent Advances

 
Drug Development Progress
  • English Name：

    Microtubule-associated protein tau

  • Category：

  • Approved Drugs：

    1 Details

  • Drugs in Clinical Trials：

    38 Details

  • Highest Development Stage：

    Phase 3 Clinical

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