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Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (MALS & SPR verified)

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NE2-V5249-100ug
$360.00
NE2-V5249-1mg
$2760.00
ETA of in-stock products:2 business days
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Product Details

  • Synonym

    Neuraminidase/NA (Influenza Virus)

  • Source

    Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (NE2-V5249) is expressed from human 293 cells (HEK293). It contains AA Lys 80 - Ile 469 (Accession # EPI_ISL_2233240, GISAID).

    Predicted N-terminus: His

    Request for sequence

  • Molecular Characterization

    Neuraminidase/NA (Influenza Virus) Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 51 kDa. The protein migrates as 70-90 kDa and 170 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a tetramer.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Neuraminidase/NA (Influenza Virus) SDS-PAGE

    Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Neuraminidase/NA (Influenza Virus) SEC-MALS

    The purity of Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (Cat. No. NE2-V5249) is more than 90% and the molecular weight of this protein is around 270-300 kDa verified by SEC-MALS.

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  • Bioactivity-SPR

    Neuraminidase/NA (Influenza Virus) SPR

    a-Neu5Ac-PAA-biotin immobilized on SA Chip can bind Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (Cat. No. NE2-V5249) with an affinity constant of 36.3 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

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