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TRAIL R1

TRAIL R1 Overview

English NameTumor necrosis factor receptor superfamily member 10AApproved Drugs1
Drugs in Clinical Trials4Target SynonymTRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
Highest Development StageApproved
English NameTumor necrosis factor receptor superfamily member 10A
Target SynonymTRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
Approved Drugs1
Drugs in Clinical Trials4
Highest Development StageApproved

TRAIL R1 Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (2)

  • Tag

    His Tag (1)Fc Tag (1)

  • Conjugate

    Unconjugated (2)

Total: 2
  • 1

TRAIL R1 Background

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

TRAIL R1 Synonyms

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

Product Reviews

  • 1***22019-09-30
    0People Like
    Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
    I purchased TNFRSF10A to measure the binding. I tested the purity first. From the results of the SEC (see attachment), you can see the purity is pretty good, 94.8%.
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