Select Language
Free Registration

TL1A

TL1A Overview

English NameTumor necrosis factor superfamily member 15Approved Drugs0
Drugs in Clinical Trials10Target SynonymVEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
Highest Development StagePhase 3 Clinical
English NameTumor necrosis factor superfamily member 15
Target SynonymVEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
Approved Drugs0
Drugs in Clinical Trials10
Highest Development StagePhase 3 Clinical

TL1A Product List

  • Product Category

    Protein (10)Cell (4)Kits (2)

  • Product Status

    Launched (16)

  • Species

    Human (11)Cynomolgus / Rhesus macaque (1)Mouse (2)Rat (1)Rabbit (1)

  • Tag

    His Tag (6)His Tag & Avi Tag (1)- (8)Fc Tag (1)

  • Conjugate

    Unconjugated (9)Biotin-labeled (1)- (6)

Total: 16
  • 1
  • 2

TL1A Background

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

TL1A Synonyms

TL1A, VEGI, TNFSF15

Product Reviews

  • Overview
  • Product List