Select Language
Free Registration

TFPI

TFPI Overview

English NameTissue factor pathway inhibitorApproved Drugs2
Drugs in Clinical Trials3Target SynonymTFPI，Tissue Factor Pathway Inhibitor，Extrinsic Pathway Inhibitor，TFPI1，LACI，EPI，Anti-Convertin，TFI，Lipoprotein-associated coagulation inhibitor，Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor)
Highest Development StageApproved
English NameTissue factor pathway inhibitor
Target SynonymTFPI，Tissue Factor Pathway Inhibitor，Extrinsic Pathway Inhibitor，TFPI1，LACI，EPI，Anti-Convertin，TFI，Lipoprotein-associated coagulation inhibitor，Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor)
Approved Drugs2
Drugs in Clinical Trials3
Highest Development StageApproved

TFPI Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Total: 1
  • 1

TFPI Background

Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N­terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C­terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C­terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.

TFPI Synonyms

TFPI,LACI,TFPI1,EPI,TFI
  • Overview
  • Product List