Select Language
Free Registration

Sonic Hedgehog

Sonic Hedgehog Overview

English NameSonic Hedgehog HomologApproved Drugs0
Drugs in Clinical Trials4Target SynonymHHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
Highest Development StagePhase 2 Clinical
English NameSonic Hedgehog Homolog
Target SynonymHHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
Approved Drugs0
Drugs in Clinical Trials4
Highest Development StagePhase 2 Clinical

Sonic Hedgehog Product List

  • Product Category

    Protein (3)

  • Product Status

    Launched (3)

  • Species

    Human (3)

  • Tag

    His Tag (1)Tag Free (2)

  • Conjugate

    Unconjugated (3)

Total: 3
  • 1

Sonic Hedgehog Background

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog Synonyms

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS
  • Overview
  • Product List