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NRG1 Beta 1

NRG1 Beta 1 Overview

English NameNeuregulin-1Approved Drugs0
Drugs in Clinical Trials0Target SynonymSensory and motor neuron-derived factor，Pro-neuregulin-1， membrane-bound isoform，Glial growth factor，Neuregulin-1，Acetylcholine receptor-inducing activity，Pro-NRG1，ARIA，Breast cancer cell differentiation factor p45，Neu differentiation factor，Heregulin，HRG
Highest Development StagePreclinical
English NameNeuregulin-1
Target SynonymSensory and motor neuron-derived factor，Pro-neuregulin-1， membrane-bound isoform，Glial growth factor，Neuregulin-1，Acetylcholine receptor-inducing activity，Pro-NRG1，ARIA，Breast cancer cell differentiation factor p45，Neu differentiation factor，Heregulin，HRG
Approved Drugs0
Drugs in Clinical Trials0
Highest Development StagePreclinical

NRG1 Beta 1 Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (2)

  • Tag

    Fc Tag (1)His Tag (1)

  • Conjugate

    Unconjugated (2)

Total: 2
  • 1

NRG1 Beta 1 Background

NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

NRG1 Beta 1 Synonyms

NRG1 Beta 1,HRG1 beta 1,Neuregulin-1 beta 1,Neuregulin1 beta 1,NRG1,ARIA,GGF,HGL,HRGA,NDF,SMDF
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