Select Language
Free Registration

NOTCH2

NOTCH2 Overview

English NameNeurogenic locus notch homolog protein 2Approved Drugs0
Drugs in Clinical Trials0Target SynonymN2ECD，NOTCH2，N2ICD，Notch 2，hN2，Neurogenic Locus Notch Homolog Protein 2，Notch (Drosophila) Homolog 2，Notch Homolog 2 (Drosophila)，Notch Homolog 2，HJCYS，AGS2，Receptor， Notch2，Notch Receptor 2
Highest Development StagePreclinical
English NameNeurogenic locus notch homolog protein 2
Target SynonymN2ECD，NOTCH2，N2ICD，Notch 2，hN2，Neurogenic Locus Notch Homolog Protein 2，Notch (Drosophila) Homolog 2，Notch Homolog 2 (Drosophila)，Notch Homolog 2，HJCYS，AGS2，Receptor， Notch2，Notch Receptor 2
Approved Drugs0
Drugs in Clinical Trials0
Highest Development StagePreclinical

NOTCH2 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    Fc Tag (1)

  • Conjugate

    Unconjugated (1)

Total: 1
  • 1

NOTCH2 Background

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .

NOTCH2 Synonyms

NOTCH2,hN2,N2ECD
  • Overview
  • Product List