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Melanotransferrin

Melanotransferrin Overview

English NameMelanotransferrinApproved Drugs0
Drugs in Clinical Trials2Target SynonymMelanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2
Highest Development StagePhase 1 Clinical
English NameMelanotransferrin
Target SynonymMelanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 1 Clinical

Melanotransferrin Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (1)Cynomolgus (1)

  • Tag

    His Tag (2)

  • Conjugate

    Unconjugated (2)

Total: 2
  • 1

Melanotransferrin Background

Melanotransferrin (MTF), also known as CD228, P97, MELTF and MFI2, is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. MTF expression is low in normal tissues but high in tumor and embryonic tissues. In melanoma MTF is associated with tumor metastasis and angiogenesis and upregulated in lung cancer tissue and cell lines. In the brain MTF is expressed in capillary endothelium but also in the reactive microglia associated with senile plaques in Alzheimer's disease (AD).

Melanotransferrin Synonyms

Melanotransferrin,CD228,MFI2,MAP97,MELTF
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