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M-CSF R

M-CSF R Overview

English NameColony stimulating factor 1 receptorApproved Drugs10
Drugs in Clinical Trials35Target SynonymCSFR，CD115 Antigen，FMS Proto-Oncogene，EC 2.7.10.1，CSF1R，Proto-Oncogene C-Fms，Macrophage Colony-Stimulating Factor 1 Receptor，FIM2，McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog，CSF-1R，C-FMS，Macrophage Colony Stimulating Factor I Receptor，CD115，HDLS，EC:2.7.10.1，EC 2.7.10，CSF-1-R，CSF-1 Receptor，FMS，BANDDOS，M-CSF-R，Colony Stimulating Factor 1 Receptor
Highest Development StageApproved
English NameColony stimulating factor 1 receptor
Target SynonymCSFR，CD115 Antigen，FMS Proto-Oncogene，EC 2.7.10.1，CSF1R，Proto-Oncogene C-Fms，Macrophage Colony-Stimulating Factor 1 Receptor，FIM2，McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog，CSF-1R，C-FMS，Macrophage Colony Stimulating Factor I Receptor，CD115，HDLS，EC:2.7.10.1，EC 2.7.10，CSF-1-R，CSF-1 Receptor，FMS，BANDDOS，M-CSF-R，Colony Stimulating Factor 1 Receptor
Approved Drugs10
Drugs in Clinical Trials35
Highest Development StageApproved

M-CSF R Product List

  • Product Category

    Protein (11)

  • Product Status

    Launched (11)

  • Species

    Human (4)Mouse (3)Cynomolgus (2)Canine (1)Rabbit (1)

  • Tag

    His Tag (5)Fc Tag (3)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)

  • Conjugate

    Unconjugated (9)Biotin-labeled (2)

Total: 11
  • 1
  • 2

M-CSF R Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

M-CSF R Synonyms

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
  • Overview
  • Product List