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LRRC15

LRRC15 Overview

English NameLeucine-rich repeat-containing protein 15Approved Drugs0
Drugs in Clinical Trials0Target SynonymLRRC15，Leucine-rich repeat-containing protein 15，hLib，Leucine Rich Repeat Containing 15，Leucine-Rich Repeat Protein Induced By Beta-Amyloid Homolog，LIB，Leucine-Rich Repeat Protein Induced By Beta Amyloid
Highest Development StagePreclinical
English NameLeucine-rich repeat-containing protein 15
Target SynonymLRRC15，Leucine-rich repeat-containing protein 15，hLib，Leucine Rich Repeat Containing 15，Leucine-Rich Repeat Protein Induced By Beta-Amyloid Homolog，LIB，Leucine-Rich Repeat Protein Induced By Beta Amyloid
Approved Drugs0
Drugs in Clinical Trials0
Highest Development StagePreclinical

LRRC15 Product List

  • Product Category

    Protein (14)Cell (1)Beads (1)

  • Product Status

    Launched (16)

  • Species

    Human (7)Mouse (4)Cynomolgus / Rhesus macaque (4)Rat (1)

  • Tag

    His Tag (4)His Tag & Avi Tag (4)Fc Tag (3)Fc Tag & Avi Tag (3)- (2)

  • Conjugate

    Unconjugated (7)Biotin-labeled (7)- (2)

Total: 16
  • 1
  • 2

LRRC15 Background

LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.

LRRC15 Synonyms

Leucine-rich repeat-containing protein 15,LRRC15,LIB,hLib
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