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LIGHT

LIGHT Overview

English NameTumor necrosis factor superfamily member 14Approved Drugs0
Drugs in Clinical Trials1Target SynonymCD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Highest Development StagePhase 2 Clinical
English NameTumor necrosis factor superfamily member 14
Target SynonymCD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Approved Drugs0
Drugs in Clinical Trials1
Highest Development StagePhase 2 Clinical

LIGHT Product List

  • Product Category

    Protein (6)Cell (1)

  • Product Status

    Launched (7)

  • Species

    Human (5)Cynomolgus (1)Mouse (1)

  • Tag

    Mouse IgG Fc Tag (1)His Tag (4)Fc Tag (1)- (1)

  • Conjugate

    Unconjugated (6)- (1)

Total: 7
  • 1

LIGHT Background

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

LIGHT Synonyms

CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

Product Reviews

  • E***a2021-09-23
    1People Like
    Human LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)
    We use this protein as an ELISA standard. We are interested in quantifying soluble LIGHT concentration from human serum. This active form of the protein perfectly binds its receptors and policlonal antibodies. The standard curve obtained is highly reproducible. It was very easy to find all the information in the web of AcroBiosystems and to download the CoA, which was also very descriptive.
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