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LIF

LIF Overview

English NameLeukemia inhibitory factorApproved Drugs0
Drugs in Clinical Trials2Target SynonymLIF Interleukin 6 Family Cytokine，D factor，Emfilermin，LIF，Differentiation-stimulating factor，LIF， Interleukin 6 Family Cytokine，Differentiation Inhibitory Activity，Cholinergic Differentiation Factor，Hepatocyte-Stimulating Factor III，Differentiation-Inducing Factor，Melanoma-Derived LPL Inhibitor，Human Interleukin In DA Cells，Leukemia Inhibitory Factor，HILDA，MLPLI，CDF，DIA
Highest Development StagePhase 2 Clinical
English NameLeukemia inhibitory factor
Target SynonymLIF Interleukin 6 Family Cytokine，D factor，Emfilermin，LIF，Differentiation-stimulating factor，LIF， Interleukin 6 Family Cytokine，Differentiation Inhibitory Activity，Cholinergic Differentiation Factor，Hepatocyte-Stimulating Factor III，Differentiation-Inducing Factor，Melanoma-Derived LPL Inhibitor，Human Interleukin In DA Cells，Leukemia Inhibitory Factor，HILDA，MLPLI，CDF，DIA
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 2 Clinical

LIF Product List

  • Product Category

    Protein (6)

  • Product Status

    Launched (6)

  • Species

    Human (4)Mouse (2)

  • Tag

    Tag Free (3)His Tag (2)His Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (5)Biotin-labeled (1)

Total: 6
  • 1

LIF Background

Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

LIF Synonyms

LIF,CDF,DIA,HILDA,MLPLI
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