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JAK1

JAK1 Overview

English NameTyrosine-protein kinase JAK1Approved Drugs11
Drugs in Clinical Trials45Target SynonymJAK1B，Tyrosine-protein kinase JAK1，JAK1，Janus Kinase 1，JAK1A，EC 2.7.10.2，JAK-1，JTK3，EC:2.7.10.2，EC 2.7.10
Highest Development StageApproved
English NameTyrosine-protein kinase JAK1
Target SynonymJAK1B，Tyrosine-protein kinase JAK1，JAK1，Janus Kinase 1，JAK1A，EC 2.7.10.2，JAK-1，JTK3，EC:2.7.10.2，EC 2.7.10
Approved Drugs11
Drugs in Clinical Trials45
Highest Development StageApproved

JAK1 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Total: 1
  • 1

JAK1 Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

JAK1 Synonyms

JAK1,JAK-1,JAK1A,JAK1B,Jak1
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