Select Language
Free Registration

Integrin alpha V beta 5

Integrin alpha V beta 5 Overview

English NameIntegrin alpha-V/beta-5Approved Drugs0
Drugs in Clinical Trials2Target SynonymReceptors， Vitronectin
Highest Development StagePhase 1 Clinical
English NameIntegrin alpha-V/beta-5
Target SynonymReceptors， Vitronectin
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 1 Clinical

Integrin alpha V beta 5 Product List

  • Product Category

    Protein (5)

  • Product Status

    Launched (5)

  • Species

    Human (2)Rat (1)Mouse (1)Cynomolgus (1)

  • Tag

    His Tag (3)His Tag & Avi Tag (2)

  • Conjugate

    Unconjugated (3)Biotin-labeled (2)

Total: 5
  • 1

Integrin alpha V beta 5 Background

Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Integrin alpha V beta 5 Synonyms

Integrin alpha V beta 5,ITGAV&ITGB5
  • Overview
  • Product List