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IL-31

IL-31 Overview

English NameInterleukin-31Approved Drugs0
Drugs in Clinical Trials3Target SynonymInterleukin 31，IL-31
Highest Development StagePhase 1 Clinical
English NameInterleukin-31
Target SynonymInterleukin 31，IL-31
Approved Drugs0
Drugs in Clinical Trials3
Highest Development StagePhase 1 Clinical

IL-31 Product List

  • Product Category

    Protein (6)Kits (1)

  • Product Status

    Launched (7)

  • Species

    Human (4)Cynomolgus (2)Mouse (1)

  • Tag

    His Tag (3)His Tag & Avi Tag (2)Tag Free (1)- (1)

  • Conjugate

    Unconjugated (4)Biotin-labeled (2)- (1)

Total: 7
  • 1

IL-31 Background

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

IL-31 Synonyms

IL-31,IL31,Interleukin-31
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