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HVEM

HVEM Overview

English NameTumor necrosis factor receptor superfamily member 14Approved Drugs0
Drugs in Clinical Trials0Target SynonymHerpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
Highest Development StagePreclinical
English NameTumor necrosis factor receptor superfamily member 14
Target SynonymHerpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
Approved Drugs0
Drugs in Clinical Trials0
Highest Development StagePreclinical

HVEM Product List

  • Product Category

    Protein (4)Cell (3)

  • Product Status

    Launched (7)

  • Species

    Human (7)

  • Tag

    Fc Tag (1)His Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (3)

  • Conjugate

    Unconjugated (3)Biotin-labeled (1)- (3)

Total: 7
  • 1

HVEM Background

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

HVEM Synonyms

TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270
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