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FAP

FAP Overview

English NameProlyl endopeptidase FAPApproved Drugs0
Drugs in Clinical Trials45Target SynonymPost-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP
Highest Development StagePhase 2 Clinical
English NameProlyl endopeptidase FAP
Target SynonymPost-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP
Approved Drugs0
Drugs in Clinical Trials45
Highest Development StagePhase 2 Clinical

FAP Product List

  • Product Category

    Protein (12)Beads (1)Cell (1)

  • Product Status

    Launched (14)

  • Species

    Human (9)Cynomolgus (2)Mouse (2)Rat (1)

  • Tag

    Fc Tag (2)His Tag (7)His Tag & Avi Tag (3)- (2)

  • Conjugate

    Unconjugated (5)FITC Labeled (2)Biotin-labeled (3)PE Labeled (1)- (2)AF647 Labeled (1)

Total: 14
  • 1
  • 2

FAP Background

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP Synonyms

FAP,FAPalpha,SIMP,Seprase,APCE
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